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LRP1B

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Low density lipoprotein-related protein 1B (deleted in tumors)
Identifiers
Symbols LRP1B; LRP-DIT; LRPDIT
External IDs OMIM: 608766 MGI: 2151136 HomoloGene: 56810 GeneCards: LRP1B Gene
RNA expression pattern
PBB GE LRP1B 219643 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 53353 94217
Ensembl ENSG00000168702 n/a
UniProt Q9NZR2 n/a
RefSeq (mRNA) NM_018557 XM_985447
RefSeq (protein) NP_061027 XP_990541
Location (UCSC) Chr 2:
140.71 - 142.6 Mb		 n/a
PubMed search [1] [2]

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.[1][2]

Function

LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.[3]

References

  1. ^ Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines". Cancer Res 60 (7): 1961–7. PMID 10766186. 
  2. ^ "Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53353. 
  3. ^ Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID 11384978. 

Further reading

  • Liu CX, Musco S, Lisitsina NM, et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID 11031110. 
  • Langbein S, Szakacs O, Wilhelm M, et al. (2002). "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer". Lab. Invest. 82 (5): 639–43. doi:10.1038/labinvest.3780458. PMID 12004004. 
  • Li Y, Knisely JM, Lu W, et al. (2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration". J. Biol. Chem. 277 (44): 42366–71. doi:10.1074/jbc.M207705200. PMID 12194987. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Cam JA, Zerbinatti CV, Knisely JM, et al. (2004). "The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production". J. Biol. Chem. 279 (28): 29639–46. doi:10.1074/jbc.M313893200. PMID 15126508. 
  • Tanaga K, Bujo H, Zhu Y, et al. (2005). "LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1422–8. doi:10.1161/01.ATV.0000133607.80554.09. PMID 15166012. 
  • Sonoda I, Imoto I, Inoue J, et al. (2004). "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma". Cancer Res. 64 (11): 3741–7. doi:10.1158/0008-5472.CAN-04-0172. PMID 15172977. 
  • Li Y, Lu W, Bu G (2005). "Striking differences of LDL receptor-related protein 1B expression in mouse and human". Biochem. Biophys. Res. Commun. 333 (3): 868–73. doi:10.1016/j.bbrc.2005.05.170. PMID 15963947. 
  • Pastrana DV, Hanson AJ, Knisely J, et al. (2006). "LRP 1 B functions as a receptor for Pseudomonas exotoxin". Biochim. Biophys. Acta 1741 (3): 234–9. doi:10.1016/j.bbadis.2005.06.007. PMID 16095885. 
  • Nakagawa T, Pimkhaokham A, Suzuki E, et al. (2006). "Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma". Cancer Sci. 97 (10): 1070–4. doi:10.1111/j.1349-7006.2006.00283.x. PMID 16918994. 
  • Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells". J. Biol. Chem. 282 (10): 7504–11. doi:10.1074/jbc.M608088200. PMID 17227771. 
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M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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EGF-like domain