Luteolin

Luteolin
IUPAC name	2-(3,4-Dihydroxyphenyl)- 5,7-dihydroxy-4-chromenone
Other names	Luteolol Digitoflavone Flacitran Luteoline
Identifiers
CAS number	491-70-3 Y
PubChem	5280445
SMILES	C1=CC(=C(C=C1C2=CC (=O)C3=C(C=C(C=C3O2)O)O)O)O
Properties
Molecular formula	C15H10O6
Molar mass	286.24 g/mol
Exact mass	286.047738
Y (what is this?)  (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Luteolin is a flavonoid; more specifically, it is one of the more common flavones.^[1] It is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an agent in the prevention of inflammation, a promoter of carbohydrate metabolism, and an immune system modulator. These characteristics of luteolin are also believed to play an important part in the prevention of cancer. Multiple research experiments describe luteolin as a biochemical agent that can dramatically reduce inflammation^[2] and the symptoms of septic shock.

Luteolin is most often found in leaves, but it is also seen in celery, thyme, dandelion, rinds, barks, clover blossom and ragweed pollen.^[1] It has also been isolated from Salvia tomentosa.^[3] Dietary sources include celery, green pepper, thyme, perilla, camomile tea, carrots, olive oil, peppermint, rosemary and oregano.^[4][5]

Glycosides

• Orientin, the 8-C glucoside of luteolin
• Isoorientin, the 6-C glucoside
• Luteolin-7-glucoside (Cynaroside) and Luteolin-7-diglucoside found in dandelion coffee
• Luteolin-7-rutinoside (Veronicastroside)

See also

Side Effects

Luteolin is a PDE4 inhibitor Phosphodiesterase inhibitor-4 ^[6]

http://www.ncbi.nlm.nih.gov/pubmed/19853596

... significantly reversed the xylazine/ketamine-induced anesthesia in mice.

Gastrointestinal adverse effects such as nausea, vomiting and gastric hypersecretion should be carefully monitored, whenever luteolin is used for treating allergies, asthma or chronic obstructive pulmonary disease.

References