macroglossia
(medicine) Enlargement of the tongue.
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Results for Macroglossia
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An enlarged tongue resulting from muscle hypertrophy, vascular or neurogenic tumor, or endocrine disturbance.

Macroglossia. (Sapp/Eversole/Wysocki, 2004)
Excessive size of the tongue.
| ICD-10 | Q38.2 |
|---|---|
| ICD-9 | 529.8 |
| OMIM | 153630 |
| DiseasesDB | 7689 |
| eMedicine | ent/746 |
| MeSH | D008260 |
Macroglossia is the medical term for unusual enlargement (hypertrophy) of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping.
Macroglossia is common in primary and myeloma-related amyloidosis. Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function. (Merck Manual 17th Ed.) Macroglossia is also a clinical feature in congenital hypothyroidism, rare genetic syndromes such as Beckwith-Wiedemann syndrome and immunodeficiency, centromere instability and facial anomalies syndrome, acromegaly and Hurler syndrome.
| Congenital malformations and deformations of digestive system (Q35-Q45, 749-751) | |
|---|---|
| Tongue, mouth and pharynx | Cleft lip and palate - Van der Woude syndrome - Ankyloglossia - Macroglossia - Pharyngeal pouch |
| Esophagus and upper alimentary tract | Esophageal atresia - Tracheoesophageal fistula - Esophageal web - Pyloric stenosis - Hiatus hernia |
| Intestines | Intestinal atresia - Imperforate anus - Meckel's diverticulum - Hirschsprung's disease |
| Other | Choledochal cysts - Alagille syndrome - Annular pancreas |
| See also noncongenital (K20-K93, 530-579) | |
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