Dictionary:

malate

  (măl'āt', mā'lāt')

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A salt or an ester of malic acid.

[MAL(IC ACID) + –ATE².]

A salt or ester of malic acid.

A salt of malic acid.

• m.–aspartate shuttle — system for the transfer of reducing equivalents as NADH and H+ between the site of generation in glycolysis in the cytosol and the site of oxidation in the electron transport chain for production of ATP in the mitochondria. Reducing equivalents are transported into the mitochondria as malate, using oxaloacetate as the carbon carrier. The oxaloacetate is generated from transamination of aspartate. Oxaloacetate does not have a mitochondrial transport protein.
• m. dehydrogenase, NAD-linked malate dehydrogenase — an enzyme found in the mitochondria (as part of the TCA cycle) or cytosol that participates in the reversible conversion of malate to oxaloacetate.