Marchiafava-Bignami disease

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Marchiafava-Bignami disease
Classification and external resources
ICD-10	G 37.1
ICD-9	341.8
DiseasesDB	31494
eMedicine	neuro/204
MeSH	D054319

Marchiafava-Bignami disease is a progressive neurological disease characterized by corpus callosum demyelination and necrosis and subsequent atrophy.

Contents

1 Eponym
2 Causes
3 See also
4 References
5 External links

Eponym

It was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker.^[1]^[2] In this patient, Marchiafava and Bignami noticed that the middle two-thirds of the corpus callosum were necrotic.

Causes

It is classically associated with chronic alcoholics and sometimes nutritional deficiencies.

References

^ synd/2922 at Who Named It?
^ E. Marchiafava, A. Bignami. Sopra un' alterazione del corpo calloso osservata da sogetti alcoolisti. Rivista di patologia nervosa e mentale, 1903, 8 (12): 544-549.

External links

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Pathology of the nervous system, primarily CNS (G04–G47, 323–349)

Inflammation

Brain	Encephalitis (Viral encephalitis, Herpesviral encephalitis) · Cavernous sinus thrombosis · Brain abscess (Amoebic)

Spinal cord	Myelitis: Poliomyelitis · Demyelinating disease (Transverse myelitis) · Tropical spastic paraparesis · Epidural abscess

Both/either	Encephalomyelitis (Acute disseminated) Meningoencephalitis

Brain/
encephalopathy

Degenerative

Extrapyramidal and movement disorders	Basal ganglia disease: Parkinsonism (PD, Postencephalitic, NMS) · PKAN · Tauopathy (PSP) · Striatonigral degeneration · Hemiballismus · HD · OA Dyskinesia: Dystonia (Status dystonicus, Spasmodic torticollis, Meige's, Blepharospasm) · Chorea (Choreoathetosis) · Myoclonus (Myoclonic epilepsy) · Akathesia Tremor (Essential tremor, Intention tremor) · Restless legs · Stiff person

Dementia	Tauopathy: Alzheimer's (Early-onset) · Frontotemporal dementia/Frontotemporal lobar degeneration (Pick's, Dementia with Lewy bodies) Multi-infarct dementia

Mitochondrial disease	Leigh's disease

Demyelinating

autoimmune (Multiple sclerosis, Neuromyelitis optica, Schilder's disease) · hereditary (Adrenoleukodystrophy, Alexander, Canavan, Krabbe, ML, PMD, VWM, MFC, CAMFAK syndrome) · Central pontine myelinolysis · Marchiafava-Bignami disease · Alpers' disease

Episodic/
paroxysmal

Seizure/epilepsy	Focal · Generalised · Status epilepticus · Myoclonic epilepsy

Headache	Migraine (Familial hemiplegic) · Cluster · Tension

Cerebrovascular	TIA (Amaurosis fugax, Transient global amnesia) Stroke (MCA, ACA, PCA, Foville's, Millard-Gubler, Lateral medullary, Weber's, Lacunar stroke)

Sleep disorders	Insomnia · Hypersomnia · Sleep apnea (Obstructive, Ondine's curse) · Narcolepsy · Cataplexy · Kleine-Levin · Circadian rhythm sleep disorder (Advanced sleep phase disorder, Delayed sleep phase disorder, Non-24-hour sleep-wake disorder, Jet lag)

CSF

Intracranial hypertension (Hydrocephalus/NPH, Idiopathic intracranial hypertension) · Cerebral edema · Intracranial hypotension

Other

Brain herniation · Reye's · Hepatic encephalopathy · Toxic encephalopathy

Spinal cord/
myelopathy

Syringomyelia · Syringobulbia · Morvan's syndrome · Vascular myelopathy (Foix-Alajouanine syndrome) · Spinal cord compression

Both/either

Degenerative

SA	Friedreich's ataxia · Ataxia telangiectasia

MND	UMN only: PLS · PP · HSP LMN only: PMA · PBP (Fazio-Londe, Infantile progressive bulbar palsy) · Spinal muscular atrophies (SMA, SMARD1, SBMA, SMAX2, SMA-PCH, SMA-LED) both: ALS

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)

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