MARCO
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MARCO
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| Macrophage receptor with collagenous structure | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MARCO; SCARA2 | ||||||||||||
| External IDs | OMIM: 604870 MGI: 1309998 HomoloGene: 4928 GeneCards: MARCO Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8685 | 17167 | |||||||||||
| Ensembl | ENSG00000019169 | ENSMUSG00000026390 | |||||||||||
| UniProt | Q9UEW3 | Q3TF99 | |||||||||||
| RefSeq (mRNA) | NM_006770 | NM_010766.2 | |||||||||||
| RefSeq (protein) | NP_006761 | NP_034896.1 | |||||||||||
| Location (UCSC) | Chr 2: 119.7 – 119.75 Mb |
Chr 1: 122.37 – 122.4 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Macrophage receptor MARCO is a protein that in humans is encoded by the MARCO gene.[1][2][3][4]
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an intracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.[4]
References
- ^ Elomaa O, Sankala M, Pikkarainen T, Bergmann U, Tuuttila A, Raatikainen-Ahokas A, Sariola H, Tryggvason K (Mar 1998). "Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region". J Biol Chem 273 (8): 4530–8. doi:10.1074/jbc.273.8.4530. PMID 9468508.
- ^ Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, Thesleff I, Kraal G, Tryggvason K (Mar 1995). "Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages". Cell 80 (4): 603–9. doi:10.1016/0092-8674(95)90514-6. PMID 7867067.
- ^ Kangas M, Brannstrom A, Elomaa O, Matsuda Y, Eddy R, Shows TB, Tryggvason K (Jul 1999). "Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor". Genomics 58 (1): 82–9. doi:10.1006/geno.1999.5811. PMID 10331948.
- ^ a b "Entrez Gene: MARCO macrophage receptor with collagenous structure". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8685.
Further reading
- Elshourbagy NA, Li X, Terrett J et al. (2000). "Molecular characterization of a human scavenger receptor, human MARCO". Eur. J. Biochem. 267 (3): 919–26. doi:10.1046/j.1432-1327.2000.01077.x. PMID 10651831.
- Seta N, Granfors K, Sahly H et al. (2001). "Expression of host defense scavenger receptors in spondylarthropathy". Arthritis Rheum. 44 (4): 931–9. doi:10.1002/1529-0131(200104)44:4<931::AID-ANR150>3.0.CO;2-T. PMID 11315932.
- Brännström A, Sankala M, Tryggvason K, Pikkarainen T (2002). "Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO". Biochem. Biophys. Res. Commun. 290 (5): 1462–9. doi:10.1006/bbrc.2002.6378. PMID 11820786.
- Sankala M, Brännström A, Schulthess T et al. (2002). "Characterization of recombinant soluble macrophage scavenger receptor MARCO". J. Biol. Chem. 277 (36): 33378–85. doi:10.1074/jbc.M204494200. PMID 12097327.
- Mirani M, Elenkov I, Volpi S et al. (2002). "HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection". J. Immunol. 169 (11): 6361–8. PMID 12444143.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bin LH, Nielson LD, Liu X et al. (2003). "Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair". J. Immunol. 171 (2): 924–30. PMID 12847263.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Arredouani MS, Palecanda A, Koziel H et al. (2005). "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages". J. Immunol. 175 (9): 6058–64. PMID 16237101.
- Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.
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