Marginal zone B-cell lymphoma

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Marginal zone B-cell lymphoma
Classification and external resources
ICD-9	200.3
ICD-O:	M 9699/3
MeSH	D018442

Marginal zone B-cell lymphoma is a type of B-cell lymphoma presenting primarily in the marginal zone.

There are three types:^[1]^[2]

Splenic marginal zone lymphoma
Extranodal marginal zone B cell lymphoma (MALT lymphoma, or "mucosa-associated lymphoid tissue")
Nodal marginal zone B cell lymphoma (NMZL)

All three are CD5 and CD10 negative

References

^ Berger F, Felman P, Thieblemont C, et al. (March 2000). "Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients". Blood 95 (6): 1950–6. PMID 10706860. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=10706860.
^ Thieblemont C (2005). "Clinical presentation and management of marginal zone lymphomas". Hematology Am Soc Hematol Educ Program 2005: 307–13. doi:10.1182/asheducation-2005.1.307. PMID 16304396. http://www.asheducationbook.org/cgi/pmidlookup?view=long&pmid=16304396.

Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)

B cell
(lymphoma,
leukemia)
(most CD19, CD20)

By development/
marker

By infection

KSHV (Primary effusion) · EBV (Lymphomatoid granulomatosis, Post-transplant lymphoproliferative disorder) · HIV (AIDS-related lymphoma) · Helicobacter pylori (MALT lymphoma)

Cutaneous

Diffuse large B-cell lymphoma · Intravascular large B-cell lymphoma · Primary cutaneous marginal zone lymphoma · Primary cutaneous immunocytoma · Plasmacytoma · Plasmacytosis · Primary cutaneous follicular lymphoma

T/NK

T cell
(lymphoma,
leukemia)
(most CD3, CD4, CD8)

By development/
marker

TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)

prolymphocyte (Prolymphocytic)

CD30+ (Anaplastic large-cell lymphoma, Lymphomatoid papulosis type A)

Cutaneous

MF+variants	indolent: Mycosis fungoides · Pagetoid reticulosis · Granulomatous slack skin aggressive: Sézary's disease · Adult T-cell leukemia/lymphoma

Non-MF	CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma · Pleomorphic T-cell lymphoma · Lymphomatoid papulosis type B CD30+: CD30+ cutaneous T-cell lymphoma · Secondary cutaneous CD30+ large cell lymphoma · Lymphomatoid papulosis type A

Other peripheral

Hepatosplenic · Angioimmunoblastic · Enteropathy-associated T-cell lymphoma · Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma) · Subcutaneous T-cell lymphoma

By infection

HTLV-1 (Adult T-cell leukemia/lymphoma)

NK cell/
(most CD56)

Aggressive NK-cell leukemia · Blastic NK cell lymphoma

T or NK

EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma) · Large granular lymphocytic leukemia

Lymphoid+myeloid

Acute biphenotypic leukaemia

Lymphocytosis

Lymphoproliferative disorders (X-linked lymphoproliferative disease, Autoimmune lymphoproliferative syndrome) · Leukemoid reaction · Diffuse infiltrative lymphocytosis syndrome

Cutaneous lymphoid hyperplasia

Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns · Cutaneous lymphoid hyperplasia with nodular pattern · Jessner lymphocytic infiltrate of the skin

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)

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