Maria Komnene may refer to:
- Maria Comnene, Queen of Hungary (1144–1190), wife of Stephen IV of Hungary
- Maria Komnene (Porphyrogenita) (1152–1182), the Porphyrogenita, eldest daughter of the Emperor Manuel I Komnenos and Bertha of Sulzbach
- Maria Komnene, Queen of Jerusalem (c. 1150–1208/17), second wife of King Amalric I of Jerusalem and mother of Isabella of Jerusalem
- Maria Komnene of Trebizond (died 1439), third wife of Emperor John VIII Palaiologos and last Empress consort of the Byzantine Empire
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