| Princess Maria Manuela | |
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| Princess of Portugal and Asturias | |
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| Spouse | Philip, Prince of Asturias |
| Issue | |
| Carlos, Prince of Asturias | |
| Born | 15 October 1527 |
| Died | 12 August 1545 (aged 17) |
Maria Manuela, Princess of Portugal (1527–1545; Portuguese pronunciation: [mɐˈɾiɐ mɐnuˈɛlɐ]; English: Mary Emmanuella) was a daughter of King John III of Portugal and his wife Catherine of Habsburg. She was Princess of Asturias as spouse of Philip, Prince of Asturias, and between 1527 and 1535 Princess of Portugal in her own right.
Maria was born in Coimbra on 15 October 1527 and was one of the few children of John III to survive childhood. She married her double-cousin Prince Philip of Asturias (future Philip II of Spain and I of Portugal) and was the mother of Prince Carlos, a deformed child who was heir of the Spanish crown.
Maria died soon after she gave birth to Don Carlos of Spain (1545–1568) on 12 August 1545 in Valladolid, Spain.
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Maria Manuela, Princess of Portugal
Cadet branch of the House of Burgundy
Born: 15 October 1527 Died: 12 August 1545 |
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| Preceded by Afonso |
Princess of Portugal 1527–1535 |
Succeeded by Manuel |
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