Mannose-associated serine protease 1 (MASP1) is a human gene.[1][2]
The protein encoded by this gene is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase.[3]
See also
References
- ^ Takada F, Takayama Y, Hatsuse H, Kawakami M (October 1993). "A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum". Biochem. Biophys. Res. Commun. 196 (2): 1003–9. doi:10.1006/bbrc.1993.2349. PMID 8240317.
- ^ Sato T, Endo Y, Matsushita M, Fujita T (April 1994). "Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein". Int. Immunol. 6 (4): 665–9. doi:10.1093/intimm/6.4.665. PMID 8018603.
- ^ Matsushita M, Thiel S, Jensenius JC, Terai I, Fujita T (01 September 2000). "Proteolytic activities of two types of mannose-binding lectin-associated serine protease". J. Immunol. 165 (5): 2637–42. PMID 10946292. http://www.jimmunol.org/cgi/content/abstract/165/5/2637.
External links
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Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21) |
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| Digestive enzymes |
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| Coagulation |
factors: Thrombin · Factor VIIa · Factor IXa · Factor Xa · Factor XIa · Factor XIIa · Kallikrein ( PSA, KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15)
fibrinolysis: Plasmin · Plasminogen activator ( Tissue plasminogen activator · Urinary plasminogen activator)
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| Complement system |
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| Other immune system |
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| Venombin |
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