Mebendazole

A broad-spectrum anthelmintic efficient against all gastrointestinal nematodes, lungworms and Moniezia in ruminants. It is not effective against Trichuris spp. and has reduced activity against benzimidazole-resistant worm species. It is not very effective against larval forms of Taenia spp., not effective against Draschia or Habronema spp. in horses, nor against Trichostrongylus axei. It is effective against Strongylus spp., but not against migrating Strongylus vulgaris larvae nor against Trichostrongylus axei, Strongyloides spp. or Anoplocephala perfoliata. It is recommended for general use in horses and combined with metriphonate for use against bot fly larvae. It is useful in dogs but does not remove Echinococcus granulosus or Dipylidium caninum. The drug has very low toxicity but has caused severe acute hepatic necrosis in some dogs.

The noun has one meaning:

Meaning #1: an anthelmintic used to treat hookworm and pinworm and roundworm infestations

"MBZ" redirects here. For the automobile brand abbreviated as "MBZ", see Mercedes-Benz.

Mebendazole
Systematic (IUPAC) name
methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate
Identifiers
CAS number	31431-39-7
ATC code	P02CA01 QP52AC09
PubChem	4030
DrugBank	APRD01086
ChemSpider	3890
Chemical data
Formula	C16H13N3O3
Mol. mass	295.293 g/mol
SMILES	eMolecules & PubChem
Physical data
Melt. point	288.5 °C (551 °F)
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	2.5 to 5.5 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C
Legal status	?
Routes	Oral
Y(what is this?)  (verify)

Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

Contents 1 Mechanism 2 Dosage 3 Drug interactions 4 See also 5 External links 6 References

Mechanism

Mebendazole causes slow immobilization and death of the worms by selectively and irreversibly blocking the uptake of glucose.

Dosage

Oral dosage for treatment of pinworms is 100 mg per dose, with one dose taken every two weeks.^{[citation needed]} This regime is repeated two weeks later if the infection has not cleared up. The dosage may differ depending on which type of worm someone is infected with. Some available products deliver 500 mg in a single dose, effectively eliminating the intestinal worms. Dosage on the packaging of some products suggests that 100 mg is a suitable single dose tablet. However using this minimal dose may be ineffective.^{[citation needed]}

Drug interactions

Carbamazepine and Phenytoin lowers serum levels of mebendazole. Cimetidine raises serum mebendazole levels, increasing its effectiveness.^[1]

Stevens-Johnson syndrome (toxic epidermal necrolysis) when Mebendazole is combined with high doses of Metronidazole.^[2]

See also

• Metronidazole
• Janssen Pharmaceutica

External links

• Vermox (UK manufacturer's website)

References

1. ^ "Drug Interactions". http://www.medicinechestonline.co.uk/static/professional2/drug_interactions.htm. Retrieved 2008-05-06. . /// Luder PJ, et al. Treatment of hydatid disease with high oral doses of mebendazole: long-term follow-up of plasma mebendazole levels and drug interactions. Eur J Clin Pharmacol 1986; 31: 443–8
2. ^ Chen KT, Twu SJ, Chang HJ, Lin RS (March 2003). "Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan". Am J Public Health 93 (3): 489–92. doi:10.2105/AJPH.93.3.489. PMID 12604501. PMC 1447769. http://www.ajph.org/cgi/pmidlookup?view=long&pmid=12604501. 

v • d • e Antiparasitics – Anthelmintics (P02) Antiplatyhelmintic agents Antitrematodals (schistosomicides) Binds tubulin benzimidazole (Triclabendazole#) AI phosphonic acid (Metrifonate) Other/unknown quinoline (Praziquantel#, Oxamniquine#) · phenol (Bithionol) · thiazole (Niridazole) · arylsulfonate (Stibophen) Anticestodals (taeniacides) Binds tubulin benzimidazole (Albendazole#) Other/unknown salicylanilide (Niclosamide)# · aminoacridine (Quinacrine) · butyrophenone (Desaspidin) · chlorophenol (Dichlorophen) Antinematodal agents (macrofilaricides) Binds tubulin benzimidazole (Mebendazole#, Thiabendazole, Albendazole#, Fenbendazole, Ciclobendazole, Flubendazole) Chloride channel macrolide (Ivermectin#) NMDA tetrahydropyrimidine (Pyrantel#, Pyrantel pamoate, Oxantel) Other/unknown piperazine (Piperazine · Diethylcarbamazine#) · thiazole (Levamisole#) · quinolinium (Pyrvinium) · benzylammonium (Bephenium) · naphthalenesulfonate (Suramin#)  · Tribendimidine #WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III see also diseases

This pharmacology-related article is a stub. You can help Wikipedia by expanding it. v • d • e

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)