Mebhydrolin

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Mebhydrolin

Systematic (IUPAC) name
5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	Not established^[1]
Legal status	?
Routes	oral^[1]
Identifiers
CAS number	524-81-2^N 6153-33-9^[2]
ATC code	R06AX15
PubChem	CID 22530
ChemSpider	21129^Y
UNII	9SUK9B7XVY^Y
KEGG	D08161^Y
Synonyms	9-Benzyl-2-methyl-2,3,4,9-tetrahydro-1H-β-carboline, Incidal, Omeril, diazolin, Fabahistin, mebhydrolin napadisylate, mebhydroline 1,5-naphthalenedisulfonate^[3]
Chemical data
Formula	C₁₉H₂₀N_2^[4]
Mol. mass	276.376 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3^Y Key:FQQIIPAOSKSOJM-UHFFFAOYSA-N^Y
N (what is this?) (verify)

Mebhydrolin (INN) or mebhydroline is an antihistamine. It is not available in the United States, but it is in various other countries. It is also called Bexidal (BD) and Diazolin (RU). It is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.

Mebhydrolin has been shown to enhance the performance-deficit effects of alcohol.^[5]

References

^ ^a ^b "FABAHISTIN 50 mg (Tablets)" (HTML). South African Electronic Package Inserts. 1970-09. http://home.intekom.com/pharm/bayer/fabahist.html. Retrieved 2007-03-02. ^{[dead link]}
^ = &term = diazoline "Diazoline" (HTML). National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode = &term = diazoline. Retrieved 2007-03-02.
^ = &term = mebhydroline "Mebhydroline" (HTML). National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode = &term = mebhydroline. Retrieved 2007-03-02.
^ "Mebhydrolin chemical information" (HTML). PubChem. http://www.chemindustry.com/chemicals/969111.html. Retrieved 2007-03-02.
^ Franks HM, Lawrie M, Schabinsky VV, Starmer GA, Teo RK (October 1981). "Interaction between ethanol and antihistamines: 3. mebhydrolin". Med. J. Aust. 2 (9): 477–9. PMID 6119605.

Histaminergics

Receptor
ligands

H₁	Agonists: 2-Pyridylethylamine Betahistine Histamine HTMT UR-AK49 Antagonists: "1st generation": 4-Methyldiphenhydramine Alimemazine Antazoline Azatadine Bamipine Benzatropine (Benztropine) Bepotastine Bromazine Brompheniramine Buclizine Captodiame Carbinoxamine Chlorcyclizine Chloropyramine Chlorothen Chlorphenamine Chlorphenoxamine Cinnarizine Clemastine Clobenzepam Clocinizine Cyclizine Cyproheptadine Dacemazine Deptropine Dexbrompheniramine Dexchlorpheniramine Dimenhydrinate Dimetindene Diphenhydramine Diphenylpyraline Doxylamine Embramine Etybenzatropine (Ethylbenztropine) Etymemazine Histapyrrodine Homochlorcyclizine Hydroxyethylpromethazine Hydroxyzine Isopromethazine Isothipendyl Meclozine Mepyramine (Pyrilamine) Mequitazine Methafurylene Methapyrilene Methdilazine Moxastine Niaprazine Orphenadrine Oxatomide Oxomemazine Phenindamine Pheniramine Phenyltoloxamine Pimethixene Piperoxan Promethazine Propiomazine Pyrrobutamine Talastine Thenalidine Thenyldiamine Thiazinamium Thonzylamine Tolpropamine Tripelennamine Triprolidine; "2nd generation": Acrivastine Astemizole Azelastine Cetirizine Clemizole Clobenztropine Ebastine Emedastine Epinastine Ketotifen Latrepirdine Levocabastine Loratadine Mebhydrolin Mizolastine Olopatadine Rupatadine Setastine Terfenadine; "3rd generation": Desloratadine Fexofenadine Levocetirizine; Miscellaneous: Tricyclic antidepressants (Amitriptyline Doxepin Trimipramine, etc) Tetracyclic antidepressants (Mianserin Mirtazapine, etc) Serotonin antagonist and reuptake inhibitors (Trazodone Nefazodone) Typical antipsychotics (Chlorpromazine Thioridazine, etc) Atypical antipsychotics (Clozapine Olanzapine Quetiapine, etc)

H₂	Agonists: Amthamine Betazole Dimaprit Histamine HTMT Impromidine UR-AK49 Antagonists: Burimamide Cimetidine Ebrotidine Famotidine Lafutidine Lavoltidine/Loxtidine Lupitidine Metiamide Niperotidine Nizatidine Oxmetidine Ranitidine Roxatidine

H₃	Agonists: α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine Methimepip Proxyfan Antagonists: A-349,821 A-423,579 ABT-239 Betahistine Burimamide Ciproxifan Clobenpropit Conessine GSK-189,254 Impentamine Iodophenpropit JNJ-5,207,852 MK-0249 NNC-38-1,049 PF-03654746 Pitolisant SCH-79,687 Thioperamide VUF-5,681

H₄	Agonists: 4-Methylhistamine Histamine VUF-8,430 Antagonists: JNJ-7,777,120 Thioperamide VUF-6,002

Reuptake
inhibitors

Vesicular

VMAT inhibitors	Ibogaine Reserpine Tetrabenazine

Enzyme
inhibitors

Anabolism

HDC inhibitors	Catechin Meciadanol Naringenin Tritoqualine

Catabolism

HNMT inhibitors	Amodiaquine Diphenhydramine Harmaline Metoprine Quinacrine SKF-91,488 Tacrine

DAO inhibitors	Aminoguanidine

Others

Precursors	L-Histidine

Cofactors	Vitamin B6 (pyridoxine pyridoxamine pyridoxal → Pyridoxal phosphate)

v t e Tricyclics

Classes	Acridine Anthracene Dibenzazepine Dibenzocycloheptene Dibenzodiazepine Dibenzothiazepine Dibenzothiepin Dibenzoxazepine Dibenzoxepin Phenothiazine Pyridazinobenzoxazine Pyridinobenzodiazepine Thioxanthene

Antidepressants	7-OH-Amoxapine Amezepine Amineptine Amitriptyline Amitriptylinoxide Amoxapine Aptazapine Azepindole Azipramine Butriptyline Cianopramine Ciclazindol Ciclopramine Clomipramine Cotriptyline Cyanodothiepin Demexiptiline Depramine/Balipramine Desipramine Dibenzepin Dimetacrine Dosulepin/Dothiepin Doxepin Enprazepine Esmirtazapine Fluotracen Hepzidine Homopipramol Imipramine Imipraminoxide Intriptyline Iprindole Ketipramine Litracen Lofepramine Losindole Loxapine Maprotiline Mariptiline Mazindol Melitracen Metapramine Mezepine Mianserin Mirtazapine Naranol Nitroxazepine Nortriptyline Noxiptiline Octriptyline Opipramol Oxaprotiline Pipofezine Pirandamine Propizepine Protriptyline Quinupramine Setiptiline/Teciptiline Tandamine Tampramine Tianeptine Tienopramine Trimipramine

Antihistamines	Alimemazine Azatadine Clobenzepam Cyproheptadine Dacemazine Deptropine Desloratadine Epinastine Etymemazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Ketotifen Latrepirdine Loratadine Mebhydrolin Mequitazine Methdilazine Olopatadine Oxomemazine Phenindamine Pimethixene Promethazine Propiomazine Rupatadine Thiazinamium

Antipsychotics	Acetophenazine Amoxapine Asenapine Butaclamol Butaperazine Carphenazine Carpipramine Chlorpromazine Chlorprothixene Ciclindole Clocapramine Clomacran Clorotepin Clotiapine Clozapine Cyanothepin Doclothepin Docloxythepin Erizepine Flucindole Flumezapine Fluotracen Flupentixol Fluphenazine Gevotroline Homopipramol Isofloxythepin Levomepromazine/Methotrimeprazine Loxapine Maroxepin Meperathiepin Mesoridazine Metitepine Metoxepin Mosapramine Naranol Octomethothepin Olanzapine Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Periciazine Piperacetazine Pipotiazine Piquindone Prochlorperazine Promazine Prothipendyl Quetiapine Sulforidazine Thiethylperazine Thiopropazate Thioridazine Thiothixene Tilozepine Trifluoperazine Triflupromazine Trifluthepin Zotepine Zuclopenthixol

Others	Atiprosin Carbamazepine Carvedilol Cyclobenzaprine Darenzepine Elanzepine Eslicarbazepine acetate Etazepine Licarbazepine Methylene Blue Monatepil Nuvenzepine Oxcarbazepine Oxitriptyline Pirenzepine Pirolate Pitrazepin Pizotifen Profenamine Rispenzepine Serazapine Siltenzepine Telenzepine Zolenzepine

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