Mecloqualone

Mecloqualone

Systematic (IUPAC) name
3-(2-chlorophenyl)-2-methylquinazolin-4(3H)-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	340-57-8 N
ATC code	None
PubChem	CID 9567
ChemSpider	9192 Y
UNII	09XU4VDV7E Y
KEGG	D04877 Y
ChEMBL	CHEMBL279960 Y
Chemical data
Formula	C15H11ClN2O
Mol. mass	270.714
SMILES	eMolecules & PubChem
InChI InChI=1S/C15H11ClN2O/c1-10-17-13-8-4-2-6-11(13)15(19)18(10)14-9-5-3-7-12(14)16/h2-9H,1H3 Y Key:SFITWQDBYUMAPS-UHFFFAOYSA-N Y
N(what is this?)  (verify)

Mecloqualone (Nubarene, Casfen) is an analogue of methaqualone which was first made in 1960^[1] and marketed mainly in France and some other European countries. It has sedative, hypnotic and anxiolytic properties, and was used for the treatment of insomnia.^[2] Mecloqualone is faster acting but shorter lasting than methaqualone and so was used only as a sleeping pill^[3], in contrast to methaqualone which was used as a general purpose anxiolytic as well. Mecloqualone was never as widely used as methaqualone and is no longer prescribed because of concerns about its potential for abuse and overdose.

See also

• Methaqualone
• Afloqualone
• Etaqualone
• Methylmethaqualone
• Mebroqualone
• Cloroqualone
• Diproqualone

References

1. ^ Jackman, G. B.; Petrow, V.; Stephenson, O. (1960). "Some 2, 3-disubstituted 3H-4-quinazolones and 3H-4-thioquinazolones". The Journal of pharmacy and pharmacology 12: 529–538. PMID 14406263.  edit
2. ^ Mouren, P.; Giraud, F.; Pinsard, N. (1963). "Clinical use of a new psycholeptic: Mecloqualone". Marseille medical 100: 599–602. PMID 13936358.  edit
3. ^ Dubnk, B.; Towne, C. A.; Bush, M. T. (1969). "Detection, assay and rate of excretion of mecloqualone in animals and man". Toxicology and applied pharmacology 15 (3): 632–641. PMID 5353825.  edit

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