Melanin concentrating hormone
Oxford Dictionary of Biochemistry:
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melanin concentrating hormone
abbr.: MCH; a neuropeptide (19 amino acids, one disulfide bond) of the intermediate lobe of the pituitary gland of teleost fishes and of the lateral hypothalamus of mammals. Infused into mice it stimulates feeding behaviour. The precursor of mammalian MCH also contains a 13-residue peptide homologous to CRH, and a 19-residue peptide homologous to GHRH. The physiological role of MCH is unclear. It acts on a G-protein-coupled membrane receptor that activates phospholipase C.
| melanin, meiosis, megaloblastic anemia | |
| melanocortin, melanocortin receptor, melanocyte |
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Melanin concentrating hormone
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Melanin concentrating hormone
| Melanin-concentrating hormone | |
|---|---|
| Identifiers | |
| Symbol | PMCH |
| Entrez | 5367 |
| HUGO | 9109 |
| OMIM | 176795 |
| RefSeq | NM_002674 |
| UniProt | P20382 |
| Other data | |
| Locus | Chr. 12 q23.2 |
Melanin-concentrating hormone (MCH) is a cyclic 19-amino acid orexinogenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish where it controls skin pigmentation.
In mammals it is involved in the regulation of feeding behavior, mood, sleep-wake cycle[1] and energy balance. MCH expressing neurons are located within the lateral hypothalamus and zona incerta. Despite this restricted distribution MCH neurons project widely throughout the brain. MCH knockout mice are hypophagic (eat less) and are lean. When administered centrally it increases food intake and weight gain.
See also
References
- ^ Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Léger L, Boissard R, Salin P, Peyron C, Luppi PH. (2003). "A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep". BMC Neurosci 4 (19). doi:10.1186/1471-2202-4-19. PMID 12964948.
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Oxford Dictionary of Biochemistry
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