MEOX2
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| Mesenchyme homeobox 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MEOX2; GAX; MOX2 | ||||||||||||
| External IDs | OMIM: 600535 MGI: 103219 HomoloGene: 4330 GeneCards: MEOX2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4223 | 17286 | |||||||||||
| Ensembl | ENSG00000106511 | ENSMUSG00000036144 | |||||||||||
| UniProt | P50222 | Q99M23 | |||||||||||
| RefSeq (mRNA) | NM_005924 | NM_008584.3 | |||||||||||
| RefSeq (protein) | NP_005915 | NP_032610.1 | |||||||||||
| Location (UCSC) | Chr 7: 15.65 – 15.73 Mb |
Chr 12: 37.84 – 37.91 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[1][2]
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[2]
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Contents
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Interactions
MEOX2 has been shown to interact with PAX1[3] and PAX3.[3]
References
- ^ LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505.
- ^ a b "Entrez Gene: MEOX2 mesenchyme homeobox 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4223.
- ^ a b Stamataki, D; Kastrinaki M, Mankoo B S, Pachnis V, Karagogeos D (Jun. 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. (Netherlands) 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. ISSN 0014-5793. PMID 11423130.
Further reading
- Grigoriou M, Kastrinaki MC, Modi WS et al. (1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3". Genomics 26 (3): 550–5. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.
- Reardon W, McManus SP, Summers D, Winter RM (1994). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2". Am. J. Med. Genet. 47 (5): 633–6. doi:10.1002/ajmg.1320470510. PMID 8266988.
- Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta 21 Suppl A: S50–4. doi:10.1053/plac.1999.0514. PMID 10831122.
- Stamataki D, Kastrinaki M, Mankoo BS et al. (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
- Gorski DH, Leal AJ (2003). "Inhibition of endothelial cell activation by the homeobox gene Gax". J. Surg. Res. 111 (1): 91–9. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.
- Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wu Z, Guo H, Chow N et al. (2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease". Nat. Med. 11 (9): 959–65. doi:10.1038/nm1287. PMID 16116430.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lin J, Friesen MT, Bocangel P et al. (2006). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Mol. Cell. Biochem. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Chen Y, Leal AD, Patel S, Gorski DH (2007). "The homeobox gene Gax activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences". J. Biol. Chem. 282 (1): 507–17. doi:10.1074/jbc.M606604200. PMC 1865102. PMID 17074759. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1865102.
External links
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