Impotence caused by medications; Drug-induced erectile dysfunction

Various medications and recreational drugs can have an affect on sexual arousal and sexual performance. It should be noted that what causes impotence in one man may not affect another.

If you think that a medication you are taking is having a negative effect on sexual performance, discuss the matter with your health care provider. NEVER stop taking any medication without first consulting your health care provider, because some medications can produce life-threatening reactions if they are not carefully and slowly stopped or switched appropriately.

The following is a list of medications and non-prescription drugs that may cause impotence:

Antidepressant and other psychiatric medications:

• Amitriptyline (Elavil)
• Amoxapine (Asendin)
• Buspirone (Buspar)
• Chlordiazepoxide (Librium)
• Chlorpromazine (Thorazine)
• Clomipramine (Anafranil)
• Clorazepate (Tranxene)
• Desipramine (Norpramin)
• Diazepam (Valium)
• Doxepin (Sinequan)
• Fluoxetine (Prozac)
• Fluphenazine (Prolixin)
• Imipramine (Tofranil)
• Isocarboxazid (Marplan)
• Lorazepam (Ativan)
• Meprobamate (Equanil)
• Mesoridazine (Serentil)
• Nortriptyline (Pamelor)
• Oxazepam (Serax)
• Phenelzine (Nardil)
• Phenytoin (Dilantin)
• Sertraline (Zoloft)
• Thioridazine (Mellaril)
• Thiothixene (Navane)
• Tranylcypromine (Parnate)
• Trifluoperazine (Stelazine)

Antihistamine medications (certain classes of antihistamines are also used to treat heartburn):

• Cimetidine (Tagamet)
• Dimenhydrinate (Dramamine)
• Diphenhydramine (Benadryl)
• Hydroxyzine (Vistaril)
• Meclizine (Antivert)
• Nizatidine (Axid)
• Promethazine (Phenergan)
• Ranitidine (Zantac)

High blood pressure medicines and diuretics ("water pills"):

• Atenolol (Tenormin)
• Bethanidine
• Bumetanide (Bumex)
• Captopril (Capoten)
• Chlorothiazide (Diuril)
• Chlorthalidone (Hygroton)
• Clonidine (Catapres)
• Enalapril (Vasotec)
• Furosemide (Lasix)
• Guanabenz (Wytensin)
• Guanethidine (Ismelin)
• Guanfacine (Tenex)
• Haloperidol (Haldol)
• Hydralazine (Apresoline)
• Hydrochlorothiazide (Esidrix)
• Labetalol (Normodyne)
• Methyldopa (Aldomet)
• Metoprolol (Lopressor)
• Minoxidil (Loniten)
• Nifedipine (Adalat, Procardia)
• Phenoxybenzamine (Dibenzyline)
• Phentolamine (Regitine)
• Prazosin (Minipress)
• Propranolol (Inderal)
• Reserpine (Serpasil)
• Spironolactone (Aldactone)
• Triamterene (Maxzide)
• Verapamil (Calan)

Among the anti-hypertensive medications, thiazides are the most common cause of ED, followed by beta-blockers. Alpha-blockers are, in general, less likely to cause this problem.

Parkinson's disease medications:

• Benztropine (Cogentin)
• Biperiden (Akineton)
• Bromocriptine (Parlodel)
• Levodopa (Sinemet)
• Procyclidine (Kemadrin)
• Trihexyphenidyl (Artane)

Chemotherapy and hormonal medications:

• Antiandrogens (Casodex, Flutamide, Nilutamide)
• Busulfan (Myleran)
• Cyclophosphamide (Cytoxan)
• Ketoconazole
• LHRH agonists (Lupron, Zoladex)

Other medications:

• Aminocaproic acid (Amicar)
• Atropine
• Clofibrate (Atromid-S)
• Cyclobenzaprine (Flexeril)
• Cyproterone
• Digoxin (Lanoxin)
• Disopyramide (Norpace)
• Estrogen
• Finasteride (Propecia, Proscar, Avodart)
• Furazolidone (Furoxone)
• H2 Blockers (Tagamet, Zantac, Pepcid)
• Indomethacin (Indocin)
• Lipid lowering-agents
• Licorice
• Metoclopramide (Reglan)
• NSAIDs (Ibuprofen, etc.)
• Orphenadrine (Norflex)
• Prochlorperazine (Compazine)
• Pseudoephedrine (Sudafed)

Opiate analgesics (painkillers)

• Codeine
• Fentanyl (Innovar)
• Hydromorphone (Dilaudid)
• Meperidine (Demerol)
• Methadone
• Morphine
• Oxycodone (Oxycontin, Percodan)

Recreational drugs:

• Alcohol
• Amphetamines
• Barbiturates
• Cocaine
• Marijuana
• Heroin
• Nicotine

Phenothiazine is a medication used to treat serious mental and emotional disorders. This article discusses an overdose of phenothiazine. Overdose occurs when someone accidentally or intentionally takes more than the normal or recommended amount of a certain substance.

This article is for information only, NOT for use in treating or managing an actual overdose. If you have overdosed or been exposed to poison, you should call your local emergency number (such as 911) or the National Poison Control Center at 1-800-222-1222.

The poisonous ingredient is phenothiazine, which may be found in a variety of medications.

• Acetophenazine
• Chlorpromazine (Thorazine)
• Chlorprothixene (Taractan)
• Clozapine (Clozaril)
• Fluphenazine (Prolixin)
• Haloperidol (Haldol)
• Loxapine (Loxitane)
• Mesoridazine (Serentil)
• Molindone (Moban)
• Perphenazine (Trilafon)
• Pimozide (Orap)
• Prochlorperazine (Compazine)
• Promazine (Sparine)
• Thioridazine (Mellaril)
• Thiothixene (Navane)
• Trifluoperazine (Stelazine)
• Triflupromazine
• Promethazine (Phenergan)

Note: This list may not be all inclusive.

• Airways and lungs
  • No breathing
  • Rapid breathing
  • Shallow breathing
• Bladder and kidneys
  • Retention of urine (unable to empty bladder)
• Eyes, ears, nose, mouth, and throat
  • Blurred vision
  • Congested nose
  • Drooling
  • Dry mouth
  • Swallowing difficulties
  • Ulcers in the mouth, on the tongue, or in the throat
  • Vision color changes (things look brownish)
  • Yellow eyes
• Heart and blood
  • High or severely low blood pressure
  • Irregular heartbeat
  • Rapid heartbeat
• Muscles and joints
  • Muscle spasms, particularly of the neck, face, and back
  • Muscle stiffness
• Nervous system
  • Agitation
  • Clumsiness
  • Coma
  • Confusion
  • Convulsions
  • Deep sleep
  • Difficulty walking or shuffling gait
  • Fainting
  • Hallucinations (rare)
  • Incoordination
  • Irritability
  • Needing to move, restlessness
  • Tremor
  • Weakness
• Skin
  • Rapid sunburn if exposed to the sun
  • Skin discoloration, bluish (changing to purplish)
• Stomach and intestinal tract
  • Constipation
  • Loss of appetite
  • Nausea
• Other
  • Changes in menstrual pattern (in women, from chronic doses)
  • Fever
  • Low body temperature (hypothermia)

Seek immediate medical help.

Do NOT make a person throw up unless told to do so by poison control or a health care professional.

Determine the following information:

• Patient's age, weight, and condition
• The name of the product (ingredients and strengths, if known)
• The amount swallowed
• The time it was swallowed
• If the medication was prescribed for the patient

The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

Take the container with you to the hospital, if possible.

See: Poison control center - emergency number

The health care provider will measure and monitor the patient's vital signs, including temperature, pulse, breathing rate, and blood pressure. Symptoms will be treated as appropriate. The patient may receive:

• Activated charcoal
• Breathing support
• Fluids through a vein (IV)
• Laxative
• Medication to help reverse the effect of the poison
• Tube through the mouth into the stomach to empty the stomach (gastric lavage)

Recovery depends on the amount of damage. Survival past 2 days is usually a good sign. The most serious side effects are usually due to damage to the heart. If heart damage can be stabilized, recovery is likely.

Nockowitz RA, Rund DA. Psychotropic medications. In: Tintinalli JE, Kelen GD, Stapczynski JS, Ma OJ, Cline DM, eds. Emergency Medicine: A Comprehensive Study Guide. 6th ed. New York, NY: McGraw-Hill; 2004:chap 290.