Metanephrine

(biochemistry) An inactive metabolite of epinephrine (3-O-methylepinephrine) that is excreted in the urine; it is recovered and measured as a test for pheochromocytoma.

One of the two principal urinary metabolites of epinephrine and norepinephrine in the urine, the other being vanillylmandelic acid.

A urinary metabolite of epinephrine.

Metanephrine
IUPAC name	4-(1-hydroxy-2-methylamino-ethyl)- 2-methoxy-phenol
Identifiers
CAS number	5001-33-2
PubChem	21100
MeSH	Metanephrine
Properties
Molecular formula	C10H15NO3
Molar mass	197.231 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Metanephrine is a metabolite of epinephrine created by action of catechol-O-methyl transferase on epinephrine. A March 20, 2002 article in the Journal of the American Medical Association indicated that the measurement of plasma free metanephrines is the best tool in the diagnosis of pheochromocytoma, an adrenal medullary neoplasm.^[1]

epinephrine

See also

• Normetanephrine

References

1. ^ Lenders J, Pacak K, Walther M, Linehan W, Mannelli M, Friberg P, Keiser H, Goldstein D, Eisenhofer G (2002). "Biochemical diagnosis of pheochromocytoma: which test is best?". JAMA 287 (11): 1427–34. doi:10.1001/jama.287.11.1427. PMID 11903030.  Free full text with registration

v • d • e Neurotransmitter metabolic intermediates catecholamines Anabolism (tyrosine→epinephrine) Tyrosine → Levodopa → Dopamine → Norepinephrine → Epinephrine Catabolism/ metabolites dopamine: DOPAL · DOPAC · MOPET · Hydroxytyrosol · 3-Methoxytyramine · Homovanillic acid norepinephrine: 3,4-Dihydroxymandelic acid · Normetanephrine · Vanillylmandelic acid · 3-Methoxy-4-hydroxyphenylglycol · Dihydroxyphenylethylene glycol epinephrine: Metanephrine tryptophan→serotonin anabolism: 5-Hydroxytryptophan catabolism: 5-Hydroxyindoleacetic acid serotonin→melatonin Normelatonin see also enzymes

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