Methimepip

Methimepip
IUPAC name 4-(1H-imidazol-4-ylmethyl)-1-methylpiperidine
Identifiers
CAS number	151070-80-3 Y
PubChem	11313837
ChEMBL	CHEMBL175782 N
IUPHAR ligand	1254
Jmol-3D images	Image 1
SMILES CN1CCC(CC1)CC2=CN=CN2
Properties
Molecular formula	C10H17N3
Molar mass	179.262 g/mol
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Methimepip is a histamine agonist which is highly selective for the H₃ subtype. It is the N-methyl derivative of immepip.^[1]

References

1. ^ Kitbunnadaj R, Hashimoto T, Poli E, et al. (March 2005). "N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist". Journal of Medicinal Chemistry 48 (6): 2100–7. doi:10.1021/jm049475h. PMID 15771452. 

v t e Histaminergics Receptor ligands H1 Agonists: 2-Pyridylethylamine Betahistine Histamine HTMT UR-AK49 Antagonists: "1st generation": 4-Methyldiphenhydramine Alimemazine Antazoline Azatadine Bamipine Benzatropine (Benztropine) Bepotastine Bromazine Brompheniramine Buclizine Captodiame Carbinoxamine Chlorcyclizine Chloropyramine Chlorothen Chlorphenamine Chlorphenoxamine Cinnarizine Clemastine Clobenzepam Clocinizine Cyclizine Cyproheptadine Dacemazine Deptropine Dexbrompheniramine Dexchlorpheniramine Dimenhydrinate Dimetindene Diphenhydramine Diphenylpyraline Doxylamine Embramine Etybenzatropine (Ethylbenztropine) Etymemazine Histapyrrodine Homochlorcyclizine Hydroxyethylpromethazine Hydroxyzine Isopromethazine Isothipendyl Meclozine Mepyramine (Pyrilamine) Mequitazine Methafurylene Methapyrilene Methdilazine Moxastine Niaprazine Orphenadrine Oxatomide Oxomemazine Phenindamine Pheniramine Phenyltoloxamine Pimethixene Piperoxan Promethazine Propiomazine Pyrrobutamine Talastine Thenalidine Thenyldiamine Thiazinamium Thonzylamine Tolpropamine Tripelennamine Triprolidine; "2nd generation": Acrivastine Astemizole Azelastine Cetirizine Clemizole Clobenztropine Ebastine Emedastine Epinastine Ketotifen Latrepirdine Levocabastine Loratadine Mebhydrolin Mizolastine Olopatadine Rupatadine Setastine Terfenadine; "3rd generation": Desloratadine Fexofenadine Levocetirizine; Miscellaneous: Tricyclic antidepressants (Amitriptyline Doxepin Trimipramine, etc) Tetracyclic antidepressants (Mianserin Mirtazapine, etc) Serotonin antagonist and reuptake inhibitors (Trazodone Nefazodone) Typical antipsychotics (Chlorpromazine Thioridazine, etc) Atypical antipsychotics (Clozapine Olanzapine Quetiapine, etc) H2 Agonists: Amthamine Betazole Dimaprit Histamine HTMT Impromidine UR-AK49 Antagonists: Burimamide Cimetidine Ebrotidine Famotidine Lafutidine Lavoltidine/Loxtidine Lupitidine Metiamide Niperotidine Nizatidine Oxmetidine Ranitidine Roxatidine H3 Agonists: α-Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine Methimepip Proxyfan Antagonists: A-349,821 A-423,579 ABT-239 Betahistine Burimamide Ciproxifan Clobenpropit Conessine GSK-189,254 Impentamine Iodophenpropit JNJ-5,207,852 MK-0249 NNC-38-1,049 PF-03654746 Pitolisant SCH-79,687 Thioperamide VUF-5,681 H4 Agonists: 4-Methylhistamine Histamine VUF-8,430 Antagonists: JNJ-7,777,120 Thioperamide VUF-6,002 Reuptake inhibitors Vesicular VMAT inhibitors Ibogaine Reserpine Tetrabenazine Enzyme inhibitors Anabolism HDC inhibitors Catechin Meciadanol Naringenin Tritoqualine Catabolism HNMT inhibitors Amodiaquine Diphenhydramine Harmaline Metoprine Quinacrine SKF-91,488 Tacrine DAO inhibitors Aminoguanidine Others Precursors L-Histidine Cofactors Vitamin B6 (pyridoxine pyridoxamine pyridoxal → Pyridoxal phosphate)

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