Methotrexate-induced papular eruption

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Methotrexate-induced papular eruption appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous indurated papules, usually located on the proximal extremities.^[1]

It has been suggested that it may represent a Cutaneous small-vessel vasculitis.^[2]

References

^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 181. ISBN 0-7216-2921-0.
^ Mebazaa A, Kenani N, Denguezli M, et al. (January 2008). "Methotrexate-induced papular eruption following treatment of psoriasis". Ann Pharmacother 42 (1): 138–41. doi:10.1345/aph.1K271. PMID 18094347.

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Drug reactions (Y40-Y59, E930-E949)

Adverse drug reaction/
drug eruption

antibiotics: Penicillin drug reaction · Sulfonamide hypersensitivity syndrome · Urticarial erythema multiforme · Adverse effects of fluoroquinolones

hormones: Steroid acne · Steroid folliculitis

chemotherapy: Chemotherapy-induced acral erythema · Chemotherapy-induced hyperpigmentation · Scleroderma-like reaction to taxanes · Hydroxyurea dermopathy · Exudative hyponychial dermatitis

blood: Anticoagulant-induced skin necrosis · Warfarin necrosis · Vitamin K reaction · Texier's disease

anticonvulsant: Anticonvulsant hypersensitivity syndrome

water-balance/acid-base: Allopurinol hypersensitivity syndrome

pulmonary: Leukotriene receptor antagonist-associated Churg–Strauss syndrome

vaccine: Eczema vaccinatum

other specified agents: Adverse reaction to biologic agents · Adverse reaction to cytokines · Bromoderma · Halogenoderma · Iododerma · Red man syndrome · Methotrexate-induced papular eruption

unspecified agent: Acute generalized exanthematous pustulosis · Bullous drug reaction · Drug-induced acne · Drug-induced angioedema · Drug-related gingival hyperplasia · Drug-induced lichenoid reaction · Drug-induced lupus erythematosus · Drug-induced nail changes · Drug-induced pigmentation · Drug-induced pseudolymphoma · Drug-induced urticaria · Fixed drug reaction · Stevens–Johnson syndrome · Injection site reaction · Linear IgA bullous dermatosis · Toxic epidermal necrolysis · HIV disease-related drug reaction · Photosensitive drug reaction · Serum sickness-like reaction

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