Methyldesorphine

Methyldesorphine

Systematic (IUPAC) name
(5α)-6,17-dimethyl- 6,7-didehydro- 4,5-epoxymorphinan- 3-ol
Clinical data
Pregnancy cat.	?
Legal status	Schedule I (US)
Identifiers
CAS number	16008-36-9 Y
ATC code	None
PubChem	CID 5362518
UNII	Y460N7W76B N
Synonyms	3-Hydroxy-6,N-dimethyl- 4,5-epoxymorphin-6-en
Chemical data
Formula	C18H21NO2
Mol. mass	283.36 g/mol
SMILES	eMolecules & PubChem
N (what is this?)  (verify)

Methyldesorphine is an opioid analgesic. First synthesized in Germany in 1940 and patented in the USA in 1952,^[1] it has a high potential for abuse as with any potent opioid agonist, and is sometimes found along with desomorphine as a component of the home-made opioid mixture known as "Krokodil" used in Russia and the neighboring former Soviet republics.^[2] It is approximately 15 times more potent than morphine as an analgesic^[3][4] but if the 6-7 bond is saturated, the β isomer is some 50 times more potent than morphine.

See also

• 6-Methylenedihydrodesoxymorphine

References

1. ^ US patent 2694068, George B. Payne et al, "Δ6-DESOXYMORPHINE COMPOUNDS AND PROCESS OF PRODUCING THE SAME", published 1952-08-05, issued 1954-09-11 
2. ^ Savchuk, S. A.; Barsegyan, S. S.; Barsegyan, I. B.; Kolesov, G. M. (2008). "Chromatographic study of expert and biological samples containing desomorphine". Journal of Analytical Chemistry 63 (4): 361-370. doi:10.1007/s10809-008-4009-5.  edit
3. ^ Casy AF, Parfitt RY. Opioid analgesics, chemistry and receptors. 1986, Plenum Press, New York. pp 37-38. ISBN 0-306-42130-5
4. ^ Lenz GR, Evans SM, Walters DE, Hopfinger AJ. Opiates (1986). p63. Academic Press. ISBN 978-0-12-443830-9

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