metoclopramide HCl

trade name: Clopra, Maxolon, Reglan; drug class: central dopamine receptor antagonist; action: enhances response to acetylcholine of tissue in upper GI tract, which causes contraction of gastric muscle, relaxes pyloric and duodenal segments, increases peristalsis without stimulating secretions; antiemetic action occurs centrally; uses: prevention of nausea, vomiting induced by chemotherapy, radiation, delayed gastric emptying, gastroesophageal reflux.

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