Brand names: Posicor®
Chemical formula:
- Español:
- Tabletas de mibefradil
Mibefradil tablets
What are mibefradil tablets?
MIBEFRADIL (Posicor®) is a calcium-channel blocker that was used for high blood pressure and chest pain.
NOTE: This drug is discontinued in the United States.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
• fainting
• heart problems
• coronary artery disease
• liver disease
• low blood pressure
• an unusual or allergic reaction to mibefradil, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding
How should I take this medicine?
Take mibefradil tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. You can take the tablets with or without food. Take your doses at regular intervals. Do not take your medicine more often then directed. Do not stop taking except on your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.What drug(s) may interact with mibefradil?
• alfuzosin
• alosetron
• antiinflammatory drugs (NSAIDs, such as ibuprofen)
• astemizole
• barbiturates such as phenobarbital
• bosentan
• certain antibiotics (clarithromycin, erythromycin, norfloxacin, telithromycin, troleandomycin)
• certain medicines used to treat cancer
• cilostazol
• cimetidine
• cisapride
• codeine
• cyclosporine
• dextromethorphan
• donepezil
• fentanyl
• halofantrine
• herbal or dietary supplements such as ginkgo biloba, ginseng, hawthorn, ma huang (ephedra), melatonin, St. John's wort, red yeast rice
• local anesthetics or general anesthetics
• medicines for anxiety or difficulty sleeping (examples: alprazolam, buspirone, midazolam, triazolam)
• medicines for depression or mental problems
• medicines for fungal infections (fluconazole, itraconazole, ketoconazole, voriconazole)
• medicines for heart-rhythm problems
• medicines for high cholesterol (atorvastatin, cerivastatin, lovastatin, simvastatin)
• medicines for high blood pressure or heart problems
• medicines for HIV infection or AIDS
• medicines for prostate problems
• medicines for seizures
• methadone
• monoamine oxidase inhibitors (Azilect®, Eldepryl®, Emsam®, Marplan®, Nardil®, Parnate®, Zelapar™)
• quinine
• rifampin, rifabutin or rifapentine
• sildenafil
• sirolimus
• steroid medications
• tacrolimus
• terfenadine
• water pills (diuretics)
• yohimbine
• zafirlukast
• zileuton
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking mibefradil?
Check your blood pressure and pulse rate regularly; this is important while you are taking mibefradil. Ask your prescriber or health care professional what your blood pressure and pulse rate should be and when you should contact him or her.
You may feel dizzy or lightheaded. Do not drive, use machinery, or do anything that needs mental alertness until you know how mibefradil affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks because they can make you more dizzy, increase flushing, and cause rapid heartbeats.
Do not suddenly stop taking mibefradil. Ask your prescriber or health care professional how you can gradually reduce the dose.
If you are going to have surgery, tell your prescriber or health care professional that you are taking mibefradil.
What side effects may I notice from taking mibefradil?
Side effects that you should report to your prescriber or health care professional as soon as possible:
Rare or uncommon:
• fainting spells, lightheadedness
• irregular heartbeat, chest pain, palpitations
• swelling of legs and ankles
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• drowsiness or dizziness
• facial flushing
• headache
• nausea, vomiting
• stomach pain
Where can I keep my medicine?
Keep out of the reach of children in a container that small children cannot open.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
