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miconazole

 
Dictionary: mi·con·a·zole   (mĭ-kŏn'ə-zōl') pronunciation
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n.
An antifungal used topically or parenterally.

[Alteration of MYCO- + (BE)N(ZIMID)AZOLE.]


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Dental Dictionary: miconazole
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n

trade names: Monistat, Monistat IV; drug class: antifungal; action: alters cell membranes and inhibits fungal enzymes; uses: coccidioidomycosis, candidiasis, cryptococcosis, paracoccidioidomycosis, fungal meningitis; IV used for severe infections only.

Drug Info: Miconazole
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Brand names: Aloe Vesta®Aloe Vesta® 2-n-1 AntifungalAthletes FootBaza®Cruex® Prescription StrengthDesenex® Jock ItchDesenex® PowderDesenex® Prescription StrengthFungoid®Fungoid® TinctureLotrimin® AF DeodarantLotrimin® AF Jock Itch Powder SprayLotrimin® AF PowderLotrimin® AF Powder SprayLotrimin® AF SprayM-Zole® 3M-Zole® Dual PackMicaderm™Micantin® Jock Itch SprayMicatin® Athlete's FootMicatin® Foot Liquid SprayMicatin® Jock Itch CreamMicatin® Powder SprayMicon® 7Miconazole 7 Micro-Guard®Mitrazol®Monistat® 1 Combination PackMonistat® 1 Combo PackMonistat® 3Monistat® 7Monistat® DermNeosporin AF®Ony-Clear®Vagistat®-3Yeast-X® IntZeasorb AFZeasorb® AF

Chemical formula:



Miconazole aerosol powder or liquid

What is miconazole aerosol powder or liquid?

MICONAZOLE (Cruex® miconazole, Desenex® miconazole, Micatin®, and others) is an antifungal type of antibiotic. Aerosol miconazole, either as a powder or a solution, is used to treat fungal infections such as ringworm, athlete's foot, and jock itch. These products do not treat fungal infections of the nails. Generic miconazole aerosol powder or aerosol solution is available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• diabetes mellitus
• immunosuppression, recent chemotherapy treatments, or infection with the human immunodeficiency ( HIV) virus
• other chronic health condition
• an unusual or allergic reaction to miconazole, other medicines, foods, dyes or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Miconazole aerosol products are only for external use on the skin. Follow the directions on the label. Shake well. Spray on the affected area (or into socks and shoes) from about 6 to 10 inches for the powder, OR, from about 4 to 6 inches for the liquid spray. Do not breathe in the powder or liquid spray. Do not use your medicine more often than directed. Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop using except on your prescribers advice.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. You should not self-treat any child under 2 years of age without your prescriber's advice. Supervise any child who is using this product.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What drug(s) may interact with miconazole?

Other skin products may affect the action of miconazole. Do not use any other skin products on the affected area without consulting your prescriber or health care professional. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking miconazole?

Tell your prescriber or health care professional if your symptoms do not improve in 7 days, although some fungal infections can take about 4 weeks to clear completely. In general, athlete's foot and ringworm infections should be treated for 4 weeks to reduce the risk of the infection coming back; jock-itch infections usually need 2 weeks of treatment.

Do not get miconazole spray near your eyes; if you do get any in your eyes, rinse out with plenty of cool tap water.

Be careful not to breathe in the vapor of these sprays.

Aerosol products can catch fire. Keep away from lighted matches, cigarettes and other naked flames.

After bathing make sure that your skin is quite dry. Fungal infections like moist conditions. Do not walk about barefoot.

To help prevent reinfection, wear freshly washed cotton, not synthetic, clothing.

What side effects may I notice from using miconazole?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• skin rash, severe irritation, redness, burning, or blistering

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Last updated: 12/2/2004 4:02:00 PM

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

Veterinary Dictionary: miconazole
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An imidazole antifungal agent used topically as the nitrate in the treatment of fungal and yeast infections of the skin.

Wikipedia: Miconazole
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Miconazole
Systematic (IUPAC) name
1-(2-(2,4-Dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole
Identifiers
CAS number 22916-47-8
ATC code D01AC02 A01AB09 A07AC01 G01AF04
PubChem 4189
DrugBank APRD01115
ChemSpider 4044
Chemical data
Formula C18H14Cl4N2O 
Mol. mass 416.127 g/mol
Pharmacokinetic data
Bioavailability n/a
Metabolism n/a
Half life n/a
Excretion n/a
Therapeutic considerations
Pregnancy cat.

?
Legal status

POM(UK) OTC(US)
Routes topical, vaginal
 Yes check.svgY(what is this?)  (verify)

Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, and commonly applied topically (to the skin) or mucus membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. It can also be used against certain species of Leishmania protozoa (which are a type of unicellular parasite), as these also contain ergosterol in their cell membranes. In addition to its antifungal and antiparasitic actions, it also has some limited antibacterial properties. It is marketed in various formulations under various brand names (see below).

Miconazole is also used in Ektachrome film developing (along with surfactants such as Photo-Flo) in the final rinse of the Kodak E-6 process and similar Fuji CR-56 process, replacing formaldehyde. Fuji Hunt also includes miconazole as a final rinse additive in their formulation of the process C-41RA rapid access color negative developing process.

Contents

Indications

Miconazole is mainly used externally for the treatment of athlete's foot, ringworm and jock itch. Internal application is used for oral or vaginal thrush (yeast infection). In addition the oral gel may also be used for the lip disorder angular cheilitis.

It has an advantage over nystatin in the treatment of neonatal oral thrush in that the latter is only licensed in the UK for those over the age of one month; but note the possibility for drug interactions.

Side effects

Unlike nystatin, some miconazole is absorbed by the intestinal tract when used orally (and possibly if used vaginally[1]) which may lead to drug interactions.

Of note may be interactions with anticoagulants, phenytoin, terbinafine, some newer atypical antipsychotics, ciclosporin and some statins used to treat hypercholesterolemia.

Brand names and formulations

Oral treatment: (brands: Daktarin in UK)

  • Oral gel 24 mg/ml (20 mg/g)

External skin treatment: (brands: Desenex in US and Canada (not to be confused with Tussionex, Micatin, Monistat-Derm, Daktarin in UK, Australia and Belgium, Decocort in Malaysia)

  • Topical cream: 2%.
  • Combination: 2% cream with 1% hydrocortisone (Daktacort in UK, Daktodor in Greece)

Vaginal treatment: (brands: Miconazex, Monistat, Femizol or Gyno-Daktariin in UK)

  • Pessaries: 200 mg or 100 mg
  • Vaginal cream: 2%
  • Combination: 2% cream with either 100 mg or 200 mg..

Physical properties

The solubilities of miconazole nitrate powder are 0.03% in water, 0.76% in ethanol and up to 4% in acetic acid.[2]

See also

References

  1. ^ British National Formulary '45' March 2003
  2. ^ United States Patent 5461068

External links

Medical

Photographic

v • d • e
Stomatological preparations (A01)
Caries prophylactic agents
Anti-infectives and antiseptics
Corticosteroids (Glucocorticoids)
Other
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Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07)
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Intestinal adsorbents
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Opium (Laudanum) · Codeine · Morphine (Paregoric)

crosses BBB: Diphenoxylate · Difenoxin

does not cross BBB: Loperamide
Intestinal anti-inflammatory agents
Antidiarrheal micro-organisms
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Antifungals (D01 and J02)
Wall/
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Ergosterol
inhibitors
topical: Thiabendazole
topical: (Natamycin, Nystatin#)
systemic: (Amphotericin B#)
Intracellular
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#WHO-EM. ‡Withdrawn from market. CLINICAL TRIALS: †Phase III. §Never to phase III
see also diseases
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Gynecological anti-infectives and antiseptics (G01)
Antibiotics
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Otologicals (S02)
Anti-infectives
Corticosteroids
Other otologicals

This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)

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Copyrights:

Dictionary. The American Heritage® Dictionary of the English Language, Fourth Edition Copyright © 2007, 2000 by Houghton Mifflin Company. Updated in 2009. Published by Houghton Mifflin Company. All rights reserved.  Read more
Dental Dictionary. Mosby's Dental Dictionary. Copyright © 2004 by Elsevier, Inc. All rights reserved.  Read more
Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Miconazole".  Read more