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Milrinone

 
Drug Info: Milrinone

Brand names: Primacor®

Chemical formula:



Milrinone injection

What is milrinone injection?

MILRINONE (Primacor®) makes your heartbeat stronger. Milrinone can dilate the blood vessels (make them larger) increasing the amount of blood pumped by the heart, and improve heart rate for patients with congestive heart failure. It is for short-term treatment to relieve severe symptoms of congestive heart failure; it is not a cure. Generic milrinone injections are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
• heart rhythm problems
• heart valve disease
• kidney disease
• recent heart attack
• an unusual or allergic reaction to milrinone, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Milrinone is for injection or infusion into a vein. It is given by a health-care professional in a clinic or hospital setting.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What drug(s) may interact with milrinone?

• ginger
• water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What should I watch for while taking milrinone?

You will be closely monitored to check your progress during and after you have received milrinone.

Milrinone can make you feel dizzy and lightheaded. To avoid dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older person.

What side effects may I notice from receiving milrinone?

Side effects that you should report to your prescriber or health care professional as soon as possible:
• dizziness or lightheadedness, fainting spells
• irregular heartbeats, palpitations, chest pain
• unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
• blurred vision
• diarrhea
• headache

Where can I keep my medicine?

Milrinone is for injection or infusion into a vein. It is given only by a health-care professional in a clinic or hospital setting.

Last updated: 7/1/2002

Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.

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Veterinary Dictionary: milrinone
Top

A synthetic phosphodiesterase inhibitor compound, used to provide inotropic support to the failing myocardium.

Wikipedia: Milrinone
Top
Milrinone
Systematic (IUPAC) name
2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile
Identifiers
CAS number 78415-72-2
ATC code C01CE02
PubChem 4197
DrugBank APRD00010
Chemical data
Formula C12H9N3O 
Mol. mass 211.219 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 100% (as IV bolus, infusion)
Protein binding 70 to 80%
Metabolism Hepatic (12%)
Half life 2.3 hours (mean, in CHF)
Excretion Urine (85% as unchanged drug) within 24 hours
Therapeutic considerations
Pregnancy cat.

C(US)

Legal status

Prescription only

Routes IV only

Milrinone (Primacor) is a phosphodiesterase III inhibitor. It potentiates the effect of cyclic adenosine monophosphate (cAMP).

Milrinone also enhances relaxation of the left ventricle by increasing Ca2+-ATPase activity on the cardiac sarcoplasmic reticulum. This increases calcium ion uptake.

It has positive inotropic, vasodilating and minimal chronotropic effects. It is used in the management of heart failure only when conventional treatment with vasodilators and diuretics has proven insufficient. This is due to the potentially fatal adverse effects of milrinone, including ventricular arrhythmias.

Whereas beneficial hemodynamic effects are shown (at least short-term), several studies have shown no or a negative effect on mortality rates of hospitalized patients receiving milrinone.

One negative side to the use of milrinone is the prolonged half-life (1 to 2 hours). This can result in a prolonged weaning and possible adverse outcomes from stopping this medication rapidly.

See also

External links


 
 
Learn More
inotrope
Milrinone injection
bipyridines

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Copyrights:

Drug Info. Gold Standard. Copyright © 2008 by Gold Standard. All rights reserved.  Read more
Veterinary Dictionary. Saunders Comprehensive Veterinary Dictionary 3rd Edition. Copyright © 2007 by D.C. Blood, V.P. Studdert and C.C. Gay, Elsevier. All rights reserved.  Read more
Wikipedia. This article is licensed under the Creative Commons Attribution/Share-Alike License. It uses material from the Wikipedia article "Milrinone" Read more