Minichromosome maintenance
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Minichromosome maintenance
| MCM2/3/5 family | |||||||||
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| Structure of MCM from archaeal M. Thermoautotrophicum.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | MCM | ||||||||
| Pfam | PF00493 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR001208 | ||||||||
| SMART | SM00350 | ||||||||
| PROSITE | PDOC00662 | ||||||||
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Mini Chromosome Maintenance complex, or Minichromosome Maintenance protein complex or mini-chromosome maintenance (MCM) 2-7 helicase complex has a role in both the initiation and the elongation phases of eukaryotic DNA replication, specifically the formation and elongation of the replication fork. MCM is a component of the pre-replication complex, which is a component of the licensing factor. MCM is a hexamer of six related polypeptides (mcm2-7) that form a ring structure.[3][4]
See also
References
- ^ Fletcher RJ, Bishop BE, Leon RP, Sclafani RA, Ogata CM, Chen XS (March 2003). "The structure and function of MCM from archaeal M. Thermoautotrophicum". Nat. Struct. Biol. 10 (3): 160–7. doi:10.1038/nsb893. PMID 12548282.
- ^ Borlado LR, Méndez J (February 2008). "CDC6: from DNA replication to cell cycle checkpoints and oncogenesis". Carcinogenesis 29 (2): 237–43. doi:10.1093/carcin/bgm268. PMID 18048387.
- ^ a b Cortez D, Glick G, Elledge SJ (July 2004). "Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases". Proc. Natl. Acad. Sci. U.S.A. 101 (27): 10078–83. doi:10.1073/pnas.0403410101. PMC 454167. PMID 15210935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=454167.
- ^ Carpentieri F, De Felice M, De Falco M, Rossi M, Pisani FM (April 2002). "Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus". J. Biol. Chem. 277 (14): 12118–27. doi:10.1074/jbc.M200091200. PMID 11821426.
External links
- Humphries C (2001-01-12). "Molecular Bureaucrat Tied to Replication Approval Process". Focus. Harvard Medical, Dental, and Public Health Schools. http://focus.hms.harvard.edu/2001/Jan12_2001/pathology1.html. Retrieved 2008-10-03.
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