Mometasone furoate
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mometasone furoate
A potent corticosteroid used for the treatment of psoriasis and for eczema that has not responded to other treatments, for the prevention and treatment of allergic rhinitis, including hay fever, and for the prevention of asthma. It is available, on prescription only, as a cream, ointment, scalp lotion, metered-dose nasal spray, or powder for use in a metered inhaler.
Side effects and precautions:
see corticosteroids; topical steroids. The nasal spray may cause headache, sore throat, and nasal irritation.
Proprietary preparations:
Asmanex Twisthaler (inhaler); Elocon (cream, ointment, or lotion); Nasonex (nasal spray).
| moexipril hydrochloride, modified-release preparation, modafinil | |
| monoamine oxidase inhibitors, monoclonal antibody, montelukast |
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Mometasone furoate
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| Systematic (IUPAC) name | |
| (11β,16α)-9,21-dichloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl 2-furoate | |
| Clinical data | |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | C (US) |
| Legal status | Rx Only (US) |
| Routes | topical, nasal |
| Pharmacokinetic data | |
| Bioavailability | Nasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone.[1] |
| Protein binding | 98% to 99% |
| Metabolism | hepatic |
| Half-life | 5.8 hours |
| Identifiers | |
| CAS number | 105102-22-5  83919-23-7 |
| ATC code | D07AC13 R01AD09, R03BA07 |
| PubChem | CID 441336 |
| DrugBank | DB00764 |
| ChemSpider | 390091 |
| ChEBI | CHEBI:47564 |
| ChEMBL | CHEMBL1161 |
| Synonyms | (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate |
| Chemical data | |
| Formula | C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate |
| Mol. mass | 427.361 g/mol (Mometasone) 521.4 g/mol (Furoate) |
| SMILES | eMolecules & PubChem |
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Mometasone furoate is a glucocorticosteroid used topically to reduce inflammation of the skin or in the airways. It is a prodrug of the free form, mometasone (INN).
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Contents
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Uses, administration, and pharmacodynamics
Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma[2][3] for patients unresponsive to less potent corticosteroids, and penile phimosis.[4] In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.[5]
It reduces inflammation by causing several effects:[6][7][8]
- reversing the activation of inflammatory proteins
- activating the secretion of anti-inflammatory proteins
- stabilising cell membranes
- decreasing the influx of inflammatory cells
- the exact anti-inflammatory mechanism of action is unknown
Availability
Schering-Plough markets the medication under the following brand names; Elocon (Elocom, Elomet, Elosalic) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions such as nasal sinus inflammation, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions. Essex pharma markets the medication under the brand name Ecural and Progreś Laboratories markets it under mometAid.
It is also available as a veterinary drug in an otic (ears) form for treatment of otitis externa under the brand name Mometamax.[9]
References
- ^ Zia R Tayab, Tom C Fardon, Daniel K C Lee, Kay Haggart, Lesley C McFarlane, Brian J Lipworth, and Günther Hochhaus (November 2007). "Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate". Br J Clin Pharmacol 64 (5): 698–705. doi:10.1111/j.1365-2125.2007.02919.x. PMC 2203259. PMID 17509041. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2203259.
- ^ Tan RA, Corren J (December 2008). "Mometasone furoate in the management of asthma: a review". Ther Clin Risk Manag 4 (6): 1201–8. PMC 2643101. PMID 19337427. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2643101.
- ^ Bousquet J (May 2009). "Mometasone furoate: an effective anti-inflammatory with a well-defined safety and tolerability profile in the treatment of asthma". Int. J. Clin. Pract. 63 (5): 806–19. doi:10.1111/j.1742-1241.2009.02003.x. PMID 19392928. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1368-5031&date=2009&volume=63&issue=5&spage=806.
- ^ Khope S (March 2010). "Topical mometasone furoate for phimosis". Indian pediatr 47 (3): 282. PMID 20371899.
- ^ Williams D. What does potency actually mean for inhaled corticosteroids?. The Journal Of Asthma: Official Journal Of The Association For The Care Of Asthma [serial online]. July 2005;42(6):409-417. Available from: MEDLINE with Full Text, Ipswich, MA. Accessed October 25, 2011.
- ^ Product Information: NASONEX(R) nasal spray, mometasone furoate monohydrate nasal spray. Schering Corporation, Kenilworth, NJ, 2010.
- ^ Publishers, Jones and Bartlett (2009-07-15). Nurse's Drug Handbook 2010. p. 677. ISBN 978-0-7637-7900-9. http://books.google.com/?id=9b8JiegivA8C&pg=PA677
- ^ Mani S. Kavuru (2007). "ch. 9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3. http://books.google.com/?id=Q1zF7xSRACIC
- ^ "Mometamax". Intervet USA. http://www.intervetusa.com/products/130_163343/productdetails_130_163679.aspx. Retrieved 19 June 2010.
External links
- Mometasone Furoate Oral Inhalation (MedlinePlus)
- Mometasone Furoate Nasal Inhalation (MedlinePlus)
- Nasonex Home page
- Asmanex Home page
- U.S. National Library of Medicine: Drug Information Portal - Mometasone furoate
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