Moracizine
Oxford A-Z of Medicinal Drugs:
Top
moracizine
(moricizine)
A class I anti-arrhythmic drug used to treat life-threatening arrhythmias. It is available as tablets on prescription only.
Side effects:
include dizziness, nervousness, 'pins and needles', gastrointestinal upset, dry mouth, sweating, chest pain, muscle pain, sleep disorders, blurred vision.
Precautions:
moracizine should not be taken by people with liver or kidney disease, if congestive heart failure is present, or by pregnant women. See also anti-arrhythmic drugs.
| montelukast, monoclonal antibody, monoamine oxidase inhibitors | |
| morphine, moxifloxacin, moxisylyte |
Wikipedia on Answers.com:
Top
Moracizine
 |
|
|---|---|
| Systematic (IUPAC) name | |
| ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate | |
| Clinical data | |
| Trade names | Ethmozine |
| AHFS/Drugs.com | Consumer Drug Information |
| MedlinePlus | a601214 |
| Pregnancy cat. | B (U.S.) |
| Legal status | ? |
| Pharmacokinetic data | |
| Bioavailability | 34–38% |
| Protein binding | 95% |
| Half-life | 3–4 hours (healthy volunteers), 6–13 hours (cardiac disease) |
| Identifiers | |
| CAS number | 31883-05-3  |
| ATC code | C01BG01 |
| PubChem | CID 34633 |
| DrugBank | DB00680 |
| ChemSpider | 31872 |
| UNII | 2GT1D0TMX1 |
| KEGG | D05077 |
| ChEBI | CHEBI:6997 |
| ChEMBL | CHEMBL1075 |
| Chemical data | |
| Formula | C22H25N3O4S |
| Mol. mass | 427.518 g/mol |
| SMILES | eMolecules & PubChem |
|
|
 (what is this?) (verify) |
|
Moracizine (INN[1], or moricizine, trade name Ethmozine) is an antiarrhythmic of class IC.[2] It was used for the prophylaxis and treatment of serious and life-threatening ventricular arrhythmias,[3] but was withdrawn in 2007 for commercial reasons.[4]
Pharmacology
Moracizine, a phenothiazine derivative, undergoes extensive first-pass metabolism and is also extensively metabolized after it has entered the circulation. It may have pharmacologically active metabolites. A clinical study has shown that moracizine is slightly less effective than encainide or flecainide in suppressing ventricular premature depolarizations.[citation needed] Compared with disopyramide and quinidine, moracizine was equally or more effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.[citation needed]
In the Cardiac Arrhythmia Suppression Trial (CAST), a large study testing the influence of antiarrhythmics on mortality, showed a non-significant increase of mortality from 5.4 to 7.2% under moracizine. This is in line with other class IC antiarrhythmics.[5]
References
- ^ "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances". World Health Organization. 2009. p. 103. http://www.who.int/medicines/services/inn/StemBook2009.pdf.
- ^ Ahmmed, G. U.; Hisatome, I.; Kurata, Y.; Makita, N.; Tanaka, Y.; Tanaka, H.; Okamura, T.; Sonoyama, K. et al (2002). "Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block". Vascular pharmacology 38 (3): 131–141. PMID 12402511.
- ^ British National Formulary (59th ed.). British Medical Journal Publishing Group, Pharmaceutical Press. 2010.
- ^ "Shire Announces Ethmozine will be Available until December 31, 2007". Heart Rhythm Society. http://www.hrsonline.org/policy/devicesdrugsfda/drugs/ethmozine_discontinued.cfm.
- ^ "Effect of the Antiarrhythmic Agent Moricizine on Survival after Myocardial Infarction". New England Journal of Medicine 327 (4): 227–233. 1992. doi:10.1056/NEJM199207233270403. PMID 1377359.
|
||||||||||||||||||||||||||||||||||||||||||||||||
 |
This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it. |
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
Post a question - any question - to the WikiAnswers community:
Copyrights:
Oxford A-Z of Medicinal Drugs
Market University Press. © 2000, 2003, 2010 An A-Z of Medicinal Drugs. All rights reserved.
Read more
