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MPDZ

 
Wikipedia: MPDZ
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Multiple PDZ domain protein
PBB Protein MPDZ image.jpg
PDB rendering based on 2fcf.
Available structures
2fcf, 2fne, 2iwn, 2iwo, 2iwp, 2iwq, 2o2t, 2opg
Identifiers
Symbols MPDZ; DKFZp781P216; FLJ25909; FLJ34626; FLJ90240; MUPP1
External IDs OMIM603785 MGI1343489 HomoloGene2841
RNA expression pattern
PBB GE MPDZ 205079 s at tn.png
PBB GE MPDZ 213306 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8777 17475
Ensembl ENSG00000107186 ENSMUSG00000028402
UniProt O75970 Q8VBX6
RefSeq NM_003829 (mRNA) NM_010820 (mRNA)
NP_003820 (protein) NP_034950 (protein)
Location Chr 9:
13.1 - 13.24 Mb
Chr 4:
80.75 - 80.91 Mb
PubMed search [1] [2]

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.[1]


Interactions

MPDZ has been shown to interact with CD117,[2] PLEKHA1[3] and 5-HT2C receptor.[4][5]

References

  1. ^ "Entrez Gene: MPDZ multiple PDZ domain protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8777. 
  2. ^ Mancini, A; Koch A, Stefan M, Niemann H, Tamura T (Sep. 2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. (NETHERLANDS) 482 (1-2): 54–8. ISSN 0014-5793. PMID 11018522. 
  3. ^ Kimber, Wendy A; Trinkle-Mulcahy Laura, Cheung Peter C F, Deak Maria, Marsden Louisa J, Kieloch Agnieszka, Watt Stephen, Javier Ronald T, Gray Alex, Downes C Peter, Lucocq John M, Alessi Dario R (Feb. 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. (England) 361 (Pt 3): 525–36. ISSN 0264-6021. PMID 11802782. 
  4. ^ Becamel, C; Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (Apr. 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. (United States) 276 (16): 12974–82. doi:10.1074/jbc.M008089200. ISSN 0021-9258. PMID 11150294. 
  5. ^ Ullmer, C; Schmuck K, Figge A, Lübbert H (Mar. 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. (NETHERLANDS) 424 (1-2): 63–8. ISSN 0014-5793. PMID 9537516. 

Further reading

  • Ullmer C, Schmuck K, Figge A, Lübbert H (1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein.". FEBS Lett. 424 (1-2): 63–8. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516. 
  • Barritt DS, Pearn MT, Zisch AH, et al. (2000). "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2.". J. Cell. Biochem. 79 (2): 213–24. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMID 10967549. 
  • Lee SS, Glaunsinger B, Mantovani F, et al. (2000). "Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins.". J. Virol. 74 (20): 9680–93. doi:10.1128/JVI.74.20.9680-9693.2000. PMID 11000240. 
  • Mancini A, Koch A, Stefan M, et al. (2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity.". FEBS Lett. 482 (1-2): 54–8. doi:10.1016/S0014-5793(00)02036-6. PMID 11018522. 
  • Becamel C, Figge A, Poliak S, et al. (2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.". J. Biol. Chem. 276 (16): 12974–82. doi:10.1074/jbc.M008089200. PMID 11150294. 
  • Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMID 11358867. 
  • Hamazaki Y, Itoh M, Sasaki H, et al. (2002). "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule.". J. Biol. Chem. 277 (1): 455–61. doi:10.1074/jbc.M109005200. PMID 11689568. 
  • Kimber WA, Trinkle-Mulcahy L, Cheung PC, et al. (2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMID 11802782. 
  • Poliak S, Matlis S, Ullmer C, et al. (2002). "Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.". J. Cell Biol. 159 (2): 361–72. doi:10.1083/jcb.200207050. PMID 12403818. 
  • Griffon N, Jeanneteau F, Prieur F, et al. (2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.". Brain Res. Mol. Brain Res. 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. 
  • Krapivinsky G, Medina I, Krapivinsky L, et al. (2004). "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.". Neuron 43 (4): 563–74. doi:10.1016/j.neuron.2004.08.003. PMID 15312654. 
  • van de Pavert SA, Kantardzhieva A, Malysheva A, et al. (2005). "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.". J. Cell. Sci. 117 (Pt 18): 4169–77. doi:10.1242/jcs.01301. PMID 15316081. 
  • Coyne CB, Voelker T, Pichla SL, Bergelson JM (2005). "The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction.". J. Biol. Chem. 279 (46): 48079–84. doi:10.1074/jbc.M409061200. PMID 15364909. 
  • Okuhira K, Fitzgerald ML, Sarracino DA, et al. (2006). "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux.". J. Biol. Chem. 280 (47): 39653–64. doi:10.1074/jbc.M510187200. PMID 16192269. 
  • Heydecke D, Meyer D, Ackermann F, et al. (2006). "The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa.". J. Androl. 27 (3): 390–404. doi:10.2164/jandrol.05166. PMID 16452527. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biology 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918. 

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