MPV may refer to:
- Multi-purpose vehicle, a type of automobile also known as a minivan
- Mazda MPV, a multi-purpose vehicle
- Mine protected vehicle
- Mean platelet volume, a measurement of the average size of platelets found in blood
- Multi-Purpose Viewer, an open-source, cross platform image generator
- Mazon-Pfizer virus
- MPV can be a file format, used by MP4 players
- British Rail MPV
- Merriweather Post Pavilion, an outdoor concert venue in Columbia, Maryland
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