MUC17
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| Mucin 17, cell surface associated | |||||||||||
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| Identifiers | |||||||||||
| Symbols | MUC17; MUC3 | ||||||||||
| External IDs | OMIM: 608424 MGI: 1203527 HomoloGene: 88635 GeneCards: MUC17 Gene | ||||||||||
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| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 140453 | 666339 | |||||||||
| Ensembl | ENSG00000169876 | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | NM_001040105 | XM_355711 | |||||||||
| RefSeq (protein) | NP_001035194 | XP_355711 | |||||||||
| Location (UCSC) | Chr 7: 100.45 - 100.49 Mb |
n/a | |||||||||
| PubMed search | [1] | [2] | |||||||||
Mucin-17 is a protein that in humans is encoded by the MUC17 gene.[1][2]
Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM][2]
References
- ^ Gum JR Jr, Crawley SC, Hicks JW, Szymkowski DE, Kim YS (Feb 2002). "MUC17, a novel membrane-tethered mucin". Biochem Biophys Res Commun 291 (3): 466–475. doi:10.1006/bbrc.2002.6475. PMID 11855812.
- ^ a b "Entrez Gene: MUC17 mucin 17, cell surface associated". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140453.
Further reading
- Kitamoto S, Yamada N, Yokoyama S et al. (2011). "DNA methylation and histone H3-K9 modifications contribute to MUC17 expression". Glycobiology 21 (2): 247–56. doi:10.1093/glycob/cwq155. PMC 3010767. PMID 20926598.
- Malmberg EK, Pelaseyed T, Petersson AC et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine". Biochem. J. 410 (2): 283–9. doi:10.1042/BJ20071068. PMID 17990980.
- Moniaux N, Junker WM, Singh AP et al. (2006). "Characterization of human mucin MUC17. Complete coding sequence and organization". J. Biol. Chem. 281 (33): 23676–23685. doi:10.1074/jbc.M600302200. PMID 16737958.
- Oh JH, Yang JO, Hahn Y et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- Ho JJ, Jaituni RS, Crawley SC et al. (2004). "N-glycosylation is required for the surface localization of MUC17 mucin". Int. J. Oncol. 23 (3): 585–92. PMID 12888891.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wang R, Khatri IA, Forstner JF (2002). "C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components". Biochem. J. 366 (Pt 2): 623–31. doi:10.1042/BJ20020289. PMC 1222797. PMID 12027806.
- Van Klinken BJ, Van Dijken TC, Oussoren E et al. (1997). "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region". Biochem. Biophys. Res. Commun. 238 (1): 143–148. doi:10.1006/bbrc.1997.7258. PMID 9299468.
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