MUC3A

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Mucin 3A, cell surface associated
Identifiers
Symbols	MUC3A; MUC-3A; MUC3
External IDs	OMIM: 158371 HomoloGene: 105104 GeneCards: MUC3A Gene
Gene Ontology Molecular function • extracellular matrix structural constituent • extracellular matrix constituent, lubricant activity Cellular component • extracellular region • membrane • integral to membrane Biological process • digestion • maintenance of gastrointestinal epithelium
Orthologs
Species	Human	Mouse
Entrez	4584	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	XM_001725354.3	n/a
RefSeq (protein)	XP_001725406.2	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

Mucin-3A is a protein that in humans is encoded by the MUC3A gene.^[1][2][3]

References

1. ^ Gum JR, Hicks JW, Swallow DM, Lagace RL, Byrd JC, Lamport DT, Siddiki B, Kim YS (Oct 1990). "Molecular cloning of cDNAs derived from a novel human intestinal mucin gene". Biochem Biophys Res Commun 171 (1): 407–15. doi:10.1016/0006-291X(90)91408-K. PMID 2393399. 
2. ^ Pratt WS, Crawley S, Hicks J, Ho J, Nash M, Kim YS, Gum JR, Swallow DM (Oct 2000). "Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B". Biochem Biophys Res Commun 275 (3): 916–23. doi:10.1006/bbrc.2000.3406. PMID 10973822. 
3. ^ "Entrez Gene: MUC3A mucin 3A, cell surface associated". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4584. 

Further reading

• Fox MF, Lahbib F, Pratt W et al. (1993). "Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22". Ann. Hum. Genet. 56 (Pt 4): 281–7. doi:10.1111/j.1469-1809.1992.tb01154.x. PMID 1362870. 
• Gum JR, Ho JJ, Pratt WS et al. (1997). "MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region". J. Biol. Chem. 272 (42): 26678–86. doi:10.1074/jbc.272.42.26678. PMID 9334251. 
• <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074. 
• Williams SJ, Munster DJ, Quin RJ et al. (1999). "The MUC3 gene encodes a transmembrane mucin and is alternatively spliced". Biochem. Biophys. Res. Commun. 261 (1): 83–9. doi:10.1006/bbrc.1999.1001. PMID 10405327. 
• Kitamoto S, Norishige Y, Seiya Y et al. (2010). "Promoter hypomethylation contributes to the expression of MUC3A in cancer cells". Biochem. Biophys. Res. Commun. 397 (2): 333–339. doi:10.1016/j.bbrc.2010.05.124. PMID 20510874. 
• Crawley SC, Gum JR, Hicks JW et al. (1999). "Genomic organization and structure of the 3' region of human MUC3: alternative splicing predicts membrane-bound and soluble forms of the mucin". Biochem. Biophys. Res. Commun. 263 (3): 728–36. doi:10.1006/bbrc.1999.1466. PMID 10512748. 
• Kyo K, Muto T, Nagawa H et al. (2001). "Associations of distinct variants of the intestinal mucin gene MUC3A with ulcerative colitis and Crohn's disease". J. Hum. Genet. 46 (1): 5–20. doi:10.1007/s100380170118. PMID 11289722. 
• Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Gum JR, Hicks JW, Crawley SC et al. (2004). "Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus". J. Biol. Chem. 278 (49): 49600–9. doi:10.1074/jbc.M305769200. PMID 12958310. 
• Leroy X, Gouyer V, Ballereau C et al. (2003). "Quantitative RT-PCR assay for MUC3 and VEGF mRNA in renal clear cell carcinoma: relationship with nuclear grade and prognosis". Urology 62 (4): 771–5. doi:10.1016/S0090-4295(03)00560-0. PMID 14550470. 

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