Mucoepidermoid carcinoma
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Mucoepidermoid carcinoma
| Mucoepidermoid carcinoma | |
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| Classification and external resources | |
 Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain. |
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| ICD-O: | 8430/3 |
| OMIM | 607536 |
| MeSH | C04.557.470.200.025.340 |
Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid.
Mucicarmine staining is one stain used by pathologist for detection.[2]
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Contents
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Epidemiology
Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]
Clinical Features
Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.
Histology
This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.
Molecular biology
Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.
Prognosis
Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.
Additional images
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Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.
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Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. The same lesion as shown in a filename "Mucoepidermoid carcinoma (2) HE stain.jpg". H & E stain.
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Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.
_HE_stain.jpg)
_HE_stain.jpg)
_AB-PAS_stain.jpg)
References
- ^ Elsevier Article Locator
- ^ Modern Pathology - Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
- ^ "Melnick M., Sedghizadeh P. P., Allen C. M., Jaskoll T.". Experimental and Molecular Pathology. 10 November 2011. doi:10.1016/j.yexmp.2011.10.011. PMID 22101257. http://www.sciencedirect.com/science/article/pii/S0014480011001869.
External links
- -489684982 at GPnotebook
- Overview at usc.edu
- Slide at jhu.edu
- mucoepidermoid carcinoma at humpath.com
- salivary mucoepidermoid carcinoma images at humpath.com
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