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Skeletal muscle relaxants have many potential drug interactions. Individual references should be consulted.
Because these drugs cause sedation, they should be used with caution with other drugs that may also cause drowsiness.
The activity of diazepam may be increased by drugs that inhibit its metabolism in the liver. These include: Cimetidine, oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol, and Valproic acid.
Dantrolene may have an interaction with estrogens. Although no interaction has been demonstrated, the rate of liver damage in women over the age of 35 who were taking estrogens is higher than in other groups.
[Article by: Samuel D. Uretsky, PharmD]
— Samuel D. Uretsky, PharmD
