MVD may refer to:
- Mitral valve disease, AKA Mitral regurgitation or mitral insufficiency
- Montevideo, capital and chief port of Uruguay
- Carrasco International Airport (IATA: MVD), Uruguay's largest airport
- Russian Ministry of Internal Affairs, Ministerstvo Vnutrennikh Del
- HC MVD, a Kontinental Hockey League ice hockey team from Balashikha
- Multi view demo, recording of a computer game
- Multivalued dependency, in database theory, a full constraint between two sets of attributes in a relation.
- The State of Arizona's equivalent of the Department of Motor Vehicles
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