| Myosin, heavy chain 1, skeletal muscle, adult |
 |
| PDB rendering based on 1m8q. |
| Available structures |
| 1m8q, 1mvw, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g |
| Identifiers |
| Symbols |
MYH1; MGC133384; MYHSA1; MYHa; MyHC-2X/D |
| External IDs |
OMIM: 160730 MGI: 1339711 HomoloGene: 68493 |
|
|
| RNA expression pattern |
 |
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
4619 |
17879 |
| Ensembl |
ENSG00000109061 |
ENSMUSG00000056328 |
| UniProt |
P12882 |
Q9WUS6 |
| RefSeq |
NM_005963 (mRNA) |
NM_030679 (mRNA) |
| NP_005954 (protein) |
NP_109604 (protein) |
| Location |
Chr 17:
10.34 - 10.36 Mb |
Chr 11:
67.02 - 67.04 Mb |
| PubMed search |
[1] |
[2] |
Myosin-1 is a protein that in humans is encoded by the MYH1 gene.[1][2]
Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.[2]
References
Further reading
- Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L (1993). "Organization of the human skeletal myosin heavy chain gene cluster.". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12078–82. doi:10.1073/pnas.89.24.12078. PMID 1465443.
- Saez L, Leinwand LA (1986). "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.". Nucleic Acids Res. 14 (7): 2951–69. doi:10.1093/nar/14.7.2951. PMID 2421254.
- Smerdu V, Karsch-Mizrachi I, Campione M, et al. (1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.". Am. J. Physiol. 267 (6 Pt 1): C1723–8. PMID 7545970.
- Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMID 10077619.
- Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
- Daugaard JR, Nielsen JN, Kristiansen S, et al. (2000). "Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.". Diabetes 49 (7): 1092–5. doi:10.2337/diabetes.49.7.1092. PMID 10909963.
- Korfage JA, Brugman P, Van Eijden TM (2000). "Intermuscular and intramuscular differences in myosin heavy chain composition of the human masticatory muscles.". J. Neurol. Sci. 178 (2): 95–106. doi:10.1016/S0022-510X(00)00372-5. PMID 11018701.
- Konig S, Burkman J, Fitzgerald J, et al. (2002). "Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family.". J. Biol. Chem. 277 (31): 27593–605. doi:10.1074/jbc.M203162200. PMID 11971910.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMID 15121898.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Pontén EM, Stål PS (2007). "Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis.". J. Neurol. Sci. 253 (1-2): 25–33. doi:10.1016/j.jns.2006.11.006. PMID 17196619.
|
PDB Gallery |
|
|
|
|
1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle
|
|
|
|
1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE
|
|
|
|
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see full disclaimer)
