MYH4

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MYH4

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myosin

PDB rendering based on 1o1g.

Available structures
PDB	1o1g, 1o1a, 1o19, 1o18, 1o1b, 1o1e, 1o1d, 1o1f, 1o1c, 1mvw, 1m8q

Identifiers

Symbols

MYH4; MYH2B

External IDs

OMIM: 160742 MGI: 1339713 HomoloGene: 23019 GeneCards: MYH4 Gene

Gene Ontology
Molecular function	• actin binding • ATP binding • motor activity • nucleotide binding • microfilament motor activity • calmodulin binding • structural constituent of muscle
Cellular component	• muscle myosin complex • myosin complex • myosin filament • sarcomere • cytoplasm • striated muscle thick filament
Biological process	• actin filament-based movement • striated muscle contraction • muscle filament sliding • response to activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
10.29 - 10.31 Mb

Chr 11:
67.05 - 67.07 Mb

PubMed search

[1]

[2]

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.^[1]

Function

MYH4 is a myosin.

References

^ Edwards YH, Parkar M, Povey S, West LF, Parrington JM, Solomon E (May 1985). "Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe". Ann. Hum. Genet. 49 (Pt 2): 101–9. doi:10.1111/j.1469-1809.1985.tb01681.x. PMID 3000272.

Sant'ana Pereira JA, Wessels A, Nijtmans L, et al. (1995). "New method for the accurate characterization of single human skeletal muscle fibres demonstrates a relation between mATPase and MyHC expression in pure and hybrid fibre types.". J. Muscle Res. Cell. Motil. 16 (1): 21–34. doi:10.1007/BF00125307. PMID 7751402.
Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15877.
Barton PJ, Buckingham ME (1985). "The myosin alkali light chain proteins and their genes.". Biochem. J. 231 (2): 249–61. PMC 1152739. PMID 3904738. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1152739.
Horton MJ, Brandon CA, Morris TJ, et al. (2001). "Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres.". Arch. Oral Biol. 46 (11): 1039–50. doi:10.1016/S0003-9969(01)00066-8. PMID 11543711.
Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Larsson L, Moss RL (1993). "Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.". J. Physiol. (Lond.) 472: 595–614. PMC 1160504. PMID 8145163. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1160504.
Li ZH, Spektor A, Varlamova O, Bresnick AR (2003). "Mts1 regulates the assembly of nonmuscle myosin-IIA.". Biochemistry 42 (48): 14258–66. doi:10.1021/bi0354379. PMID 14640694.
Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape.". Cell 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2716422.
Ford HL, Silver DL, Kachar B, et al. (1997). "Effect of Mts1 on the structure and activity of nonmuscle myosin II.". Biochemistry 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
Soussi-Yanicostas N, Whalen RG, Petit C (1993). "Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.". Hum. Mol. Genet. 2 (5): 563–9. doi:10.1093/hmg/2.5.563. PMID 8518795.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PDB gallery

1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle

Proteins of the cytoskeleton

Human

Microfilaments
(ABPs)

Myofilament

Actins	A1, A2, B, C1, G1, G2

Myosins	I (MYO1A, MYO1B, MYO1C, MYO1D, MYO1E, MYO1F, MYO1G, MYO1H) · II (MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, MYH16) · III (MYO3A, MYO3B) · V (MYO5A, MYO5B, MYO5C) · VI (MYO6) · VII (MYO7A, MYO7B) · IX (MYO9A, MYO9B) · X (MYO10) · XV (MYO15A) · XVIII (MYO18A, MYO18B) · LC (MYL1, MYL2, MYL3, MYL4, MYL5, MYL6, MYL6B, MYL7, MYL9, MYLIP, MYLK, MYLK2, MYLL1)

Other	Tropomodulin (1, 2, 3, 4) · Troponin (T 1 2 3, C 1 2, I 1 2 3) · Tropomyosin (1, 2, 3, 4) Actinin (1, 2, 3, 4) · Arp2/3 complex · actin depolymerizing factors (Cofilin (1, 2) · Destrin) · Gelsolin · Profilin (1, 2) · Titin

Other

Wiskott-Aldrich syndrome protein · Fibrillin · Filamin (FLNA, FLNB, FLNC) · Espin · TRIOBP

IFs

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 (10, 12, 13, 14, 15, 16, 17, 19, 20) · chromosome 12 (18) · none (21) type II/chromosome 12 (1, 2A, 3, 4, 5, 6A, 6B, 7, 8, 9)

Hair keratins (hard alpha-keratins)	type I/chromosome 17 (31, 32, 33A, 33B, 34, 35, 36, 37, 38) type II/chromosome 12 (81, 82, 83, 84, 85, 86)

Ungrouped alpha	chromosome 17 (23, 24, 25, 26, 27, 28, 39, 40) chromosome 12 (71, 72, 73, 74, 75, 76, 77, 78, 79, 80)

Not alpha	Beta-keratin

Type 3

Desmin, GFAP, Peripherin, Vimentin

Type 4

Internexin, Nestin, Neurofilament (NEFL, NEFM, NEFH), Synemin, Syncoilin

Type 5

Lamin A, B

Microtubules/
MAPs

Kinesins	KIF1A, KIF1B, KIF2A, KIF2C, KIF3B, KIF3C, KIF4A, KIF4B, KIF5A, KIF5B, KIF5C, KIF6, KIF7, KIF9, KIF11, KIF12, KIF13A, KIF13B, KIF14, KIF15, KIF16B, KIF17, KIF18A, KIF18B, KIF19, KIF20A, KIF20B, KIF21A, KIF21B, KIF22, KIF23, KIF24, KIF25, KIF26A, KIF26B, KIF27, KIFC1, KIFC2, KIFC3

Dyneins	axonemal: DNAH1, DNAH2, DNAH3, DNAH5, DNAH6, DNAH7, DNAH8, DNAH9, DNAH10, DNAH11, DNAH12, DNAH13, DNAH14, DNAH17, DNAI1, DNAI2, DNALI1, DNAL1, DNAL4 cytoplasmic: DYNC1H1, DYNC2H1, DYNC1I1, DYNC1I2, DYNC1LI1, DYNC1LI2, DYNC2LI1, DYNLL1, DYNLL2, DYNLRB1, DYNLRB2, DYNLT1, DYNLT3

Other	Tau protein · Dynactin (DCTN1) · Tubulins (TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8) · Stathmin · Tektin (TEKT1, TEKT2, TEKT3, TEKT4, TEKT5) · Dynamin (DNM1, DNM2, DNM3)

Catenins

Alpha catenin · Beta catenin (APC) · Plakoglobin (gamma catenin) · Delta catenin · GAN

Membrane

Dystrophin (Dystroglycan) · Utrophin · Ankyrin (ANK1, ANK2, ANK3) · Spectrin (SPTA1, SPTAN1, SPTB, SPTBN1, SPTBN2, SPTBN4, SPTBN5)

Other

plakin (Desmoplakin, Plectin) · Talin (TLN1) · Vinculin · Plakophilin (PKP1, PKP2)

Nonhuman

Major sperm proteins · Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB)

see also cytoskeletal defects
B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

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Peripherin

Tropomodulin

CAP (protein)

Actin depolymerizing factor

Major sperm protein

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MYH4

MYH4

Function

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