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MYL4

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Myosin, light chain 4, alkali; atrial, embryonic
Identifiers
Symbols MYL4; GT1; ALC1; AMLC; PRO1957
External IDs OMIM: 160770 MGI: 97267 HomoloGene: 20558 GeneCards: MYL4 Gene
RNA expression pattern
PBB GE MYL4 210395 x at tn.png
PBB GE MYL4 210088 x at tn.png
PBB GE MYL4 216054 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4635 17896
Ensembl ENSG00000198336 ENSMUSG00000061086
UniProt P12829 Q9CZ19
RefSeq (mRNA) NM_001002841 NM_010858
RefSeq (protein) NP_001002841 NP_034988
Location (UCSC) Chr 17:
42.64 - 42.66 Mb		 Chr 11:
104.37 - 104.4 Mb
PubMed search [1] [2]

Myosin light chain 4 is a protein that in humans is encoded by the MYL4 gene.[1][2]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]

References

  1. ^ Kurabayashi M, Komuro I, Tsuchimochi H, Takaku F, Yazaki Y (Oct 1988). "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones". J Biol Chem 263 (27): 13930–6. PMID 3417683. 
  2. ^ a b "Entrez Gene: MYL4 myosin, light chain 4, alkali; atrial, embryonic". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4635. 

Further reading

  • Rotter M, Zimmerman K, Poustka A, et al. (1991). "The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions". Nucleic Acids Res. 19 (7): 1497–504. doi:10.1093/nar/19.7.1497. PMC 333907. PMID 2027757. 
  • Seharaseyon J, Bober E, Hsieh CL, et al. (1990). "Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location". Genomics 7 (2): 289–93. doi:10.1016/0888-7543(90)90554-8. PMID 2129532. 
  • Zimmermann K, Kautz S, Hajdu G, et al. (1990). "Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells". J. Mol. Biol. 211 (3): 505–13. doi:10.1016/0022-2836(90)90261-J. PMID 2308163. 
  • Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299. 
  • Arnold HH, Lohse P, Seidel U, Bober E (1989). "A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria". Eur. J. Biochem. 178 (1): 53–60. doi:10.1111/j.1432-1033.1988.tb14428.x. PMID 2849544. 
  • Strohman RC, Micou-Eastwood J, Glass CA, Matsuda R (1983). "Human fetal muscle and cultured myotubes derived from it contain a fetal-specific myosin light chain". Science 221 (4614): 955–7. doi:10.1126/science.6879193. PMID 6879193. 
  • Timson DJ, Trayer IP (1997). "The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex". FEBS Lett. 400 (1): 31–6. doi:10.1016/S0014-5793(96)01314-2. PMID 9000508. 
  • Timson DJ, Trayer HR, Trayer IP (1998). "The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function". Eur. J. Biochem. 255 (3): 654–62. doi:10.1046/j.1432-1327.1998.2550654.x. PMID 9738905. 
  • Timson DJ, Trayer HR, Smith KJ, Trayer IP (1999). "Size and charge requirements for kinetic modulation and actin binding by alkali 1-type myosin essential light chains". J. Biol. Chem. 274 (26): 18271–7. doi:10.1074/jbc.274.26.18271. PMID 10373429. 
  • Morano I (1999). "Tuning the human heart molecular motors by myosin light chains". J. Mol. Med. 77 (7): 544–55. doi:10.1007/s001099900031. PMID 10494800. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Arrell DK, Neverova I, Fraser H, et al. (2001). "Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1". Circ. Res. 89 (6): 480–7. doi:10.1161/hh1801.097240. PMID 11557734. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. 
  • Abdelaziz AI, Pagel I, Schlegel WP, et al. (2006). Human Atrial Myosin Light Chain 1 Expression Attenuates Heart Failure. "Human atrial myosin light chain 1 expression attenuates heart failure". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 565: 283–92; discussion 92, 405–15. doi:10.1007/0-387-24990-7_21. ISBN 978-0-387-24989-6. PMID 16106982. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. 
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