MYL6B
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| Myosin, light chain 6B, alkali, smooth muscle and non-muscle | |||||||||||||
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 PDB rendering based on 1oe9. |
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| Identifiers | |||||||||||||
| Symbols | MYL6B; MLC1SA | ||||||||||||
| External IDs | OMIM: 609930 MGI: 1917789 HomoloGene: 86887 GeneCards: MYL6B Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 140465 | 216459 | |||||||||||
| Ensembl | ENSG00000196465 | ENSMUSG00000039824 | |||||||||||
| UniProt | P14649 | Q8CI43 | |||||||||||
| RefSeq (mRNA) | NM_001199629.1 | NM_172259.1 | |||||||||||
| RefSeq (protein) | NP_001186558.1 | NP_758463.1 | |||||||||||
| Location (UCSC) | Chr 12: 56.55 – 56.55 Mb |
Chr 10: 127.93 – 127.94 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.[1][2][3]
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.[3]
References
- ^ Zimmermann K, Starzinski-Powitz A (Feb 1990). "A novel isoform of myosin alkali light chain isolated from human muscle cells". Nucleic Acids Res 17 (24): 10496. doi:10.1093/nar/17.24.10496. PMC 335321. PMID 2602161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=335321.
- ^ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol 10 (3): 1095–104. PMC 360973. PMID 2304459. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360973.
- ^ a b "Entrez Gene: MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140465.
Further reading
- Coureux PD, Sweeney HL, Houdusse A (2005). "Three myosin V structures delineate essential features of chemo-mechanical transduction". EMBO J. 23 (23): 4527–37. doi:10.1038/sj.emboj.7600458. PMC 533045. PMID 15510214. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=533045.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell. Sci. 109 (8): 2089–99. PMID 8856505.
- Seidel U, Bober E, Winter B et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.
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