MYLIP
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| Myosin regulatory light chain interacting protein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MYLIP; MIR | ||||||||||||
| External IDs | OMIM: 610082 MGI: 2388271 HomoloGene: 8309 GeneCards: MYLIP Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 29116 | 218203 | |||||||||||
| Ensembl | ENSG00000007944 | ENSMUSG00000038175 | |||||||||||
| UniProt | Q8WY64 | Q3TAE7 | |||||||||||
| RefSeq (mRNA) | NM_013262 | XM_978411 | |||||||||||
| RefSeq (protein) | NP_037394 | XP_983505 | |||||||||||
| Location (UCSC) | Chr 6: 16.24 - 16.26 Mb |
Chr 13: 45.4 - 45.42 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[1]
MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.[2][3] The expression of IDOL is induced by the sterol-ativated liver X receptor.
Function
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[1]
References
- ^ a b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29116.
- ^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science 325 (5936): 100–4. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2777523.
- ^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294.
Further reading
- Olsson PA, Korhonen L, Mercer EA, Lindholm D (2000). "MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.". J. Biol. Chem. 274 (51): 36288–92. doi:10.1074/jbc.274.51.36288. PMID 10593918.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
- Olsson PA, Bornhauser BC, Korhonen L, Lindholm D (2001). "Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6.". Biochem. Biophys. Res. Commun. 279 (3): 879–83. doi:10.1006/bbrc.2000.4028. PMID 11162443.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bornhauser BC, Olsson PA, Lindholm D (2003). "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.". J. Biol. Chem. 278 (37): 35412–20. doi:10.1074/jbc.M306271200. PMID 12826659.
- Bornhauser BC, Johansson C, Lindholm D (2003). "Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR.". FEBS Lett. 553 (1-2): 195–9. doi:10.1016/S0014-5793(03)01010-X. PMID 14550572.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ohmura-Hoshino M, Matsuki Y, Aoki M, et al. (2006). "Inhibition of MHC class II expression and immune responses by c-MIR.". J. Immunol. 177 (1): 341–54. PMID 16785530.
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