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MYO18B

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MYO18B

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Myosin XVIIIB
Identifiers
Symbols MYO18B; DKFZp434C2422; DKFZp779C1668; FLJ41942
External IDs OMIM: 607295 MGI: 1921626 HomoloGene: 53435 GeneCards: MYO18B Gene
RNA expression pattern
PBB GE MYO18B gnf1h07674 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 84700 74376
Ensembl ENSG00000133454 ENSMUSG00000072720
UniProt Q8IUG5 n/a
RefSeq (mRNA) NM_032608 XM_912851
RefSeq (protein) NP_115997 XP_917944
Location (UCSC) Chr 22:
24.49 - 24.76 Mb		 Chr 5:
113.06 - 113.11 Mb
PubMed search [1] [2]

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.[1][2][3]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.[3]

References

  1. ^ Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A 99 (19): 12269–74. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013. 
  2. ^ Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197. 
  3. ^ a b "Entrez Gene: MYO18B myosin XVIIIB". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84700. 

Further reading

  • Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID 12741677. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Yanaihara N, Nishioka M, Kohno T, et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. Cancer 112 (1): 150–4. doi:10.1002/ijc.20339. PMID 15305387. 
  • Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID 16499872. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. PMID 17294804. 
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