N-Acetylprocainamide

N-Acetylprocainamide

Systematic (IUPAC) name
4-acetylamino-N-(2-diethylaminoethyl)benzamide
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	intravenously or orally
Identifiers
CAS number	32795-44-1
ATC code	?
PubChem	CID 4342
ChemSpider	4189
ChEMBL	CHEMBL1097 Y
Chemical data
Formula	C15H23N3O2
Mol. mass	277.36 g/mol
InChI InChI=1S/C15H23N3O2/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19) Key:KEECCEWTUVWFCV-UHFFFAOYSA-N
Y (what is this?)  (verify)

N-Acetylprocainamide (NAPA or acecainide) is the N-acetylated metabolite of procainamide. It is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug. It is only partially as active as procainamide; when checking levels both must be included in the final calculation.

Administration

It can be given either intravenously or orally, and is eliminated primarily by renal excretion. Comparative studies with other antiarrhythmic drugs have not been undertaken apart from a small study in atrial flutter where acecainide was better than quinidine plus digoxin. Although further clinical experience is required before the relative place of acecainide in therapy can be determined, the drug nevertheless appears to offer advantages over procainamide, particularly with respect to the reduced formation of antinuclear antibodies.

External links

• PubPK - N-Acetylprocainamide Pharmacokinetics

References

• Merck Index, 13th Edition, 20.
• Ger. Pat. , 1971, 2 062 978; CA , 75 , 76427, (Acecainide)