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Methiopropamine

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Methiopropamine
Systematic (IUPAC) name
1-(thiophen-2-yl)-2-methylaminopropane
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 801156-47-8 N
7464-94-0 (hydrochloride)
ATC code  ?
PubChem CID 436156
ChemSpider 385727 YesY
Chemical data
Formula C8H13NS 
Mol. mass 155.261 g/mol
SMILES eMolecules & PubChem
 N (what is this?)  (verify)

Methiopropamine (MPA) is a thiophene-based structural analog of methamphetamine originally reported in 1942.[1] It originally appeared for public sale in the UK in December 2010[2][unreliable source?][3] as a "research chemical" or "legal high", recently branded as Gogaine.[4] It gained limited popularity as a recreational stimulant due to its relatively mild euphoria in comparison to other common stimulants like amphetamine, instead being described as clear headed[5], a more functional stimulant.[6]

Long term health risks are yet to be determined due to lack of interest from the pharmaceutical industry in terms of testing the substance, and anecdotal data from recreational users is also limited.

Contents

Pharmacological effects

Due to a lack of clinical studies, only anecdotal reports exist for its effects. In line with it being an analogue of amphetamine, these reports suggest it has an action on dopaminegeric systems, most likely as a DRA. Anecdotal reports from internet forums of subjective effects include mild euphoria, increased alertness and focus,[7] energy and sexual arousal.

Side effects

 This section needs more medical references for verification. Please review the contents of the section and add the appropriate references if you can. Unsourced or poorly-sourced material may be removed.
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Ancedotal reported side effects are quite adverse on higher doses including: increased heart rate, increased sweating, discolouration of extremities, cardiovascular problems and chest pain,[citation needed] all common symptoms of vasoconstriction. A number of users have also reported stomach complaints after using,[8][9][10] particularly after re-dosing.[7]

Ancedotal reports have also included reporting it to have much more prominent negative side effects compared to common stimulants like amphetamine.

Dosage

An average dose of Methiopropamine is between 25mg-50mg orally. Insufflated is between 20mg-45mg.[11]

See also

External links

References

  1. ^ Blicke, F. F.; Burckhalter, J. H. (1942). "α-Thienylaminoalkanes". Journal of the American Chemical Society 64 (3): 477. doi:10.1021/ja01255a001.  edit
  2. ^ "The Methiopropamine thread.". http://www.bluelight.ru/vb/showthread.php?t=544266. Retrieved 2011-05-08. 
  3. ^ "Methiopropamine Vault". Erowid. 2011-07-05. http://www.erowid.org/chemicals/methiopropamine/. Retrieved 2012-03-01. 
  4. ^ Angelov, D.; O'Brien, J.; Kavanagh, P. (2011). "The syntheses of 1-(2-thienyl)-2-(methylamino) propane (methiopropamine) and its 3-thienyl isomer for use as reference standards". Drug Testing and Analysis: n/a. doi:10.1002/dta.298. PMID 21770051.  edit
  5. ^ "Methiopropamine - Effects". Erowid. 2011-07-05. http://www.erowid.org/chemicals/methiopropamine/methiopropamine_effects.shtml. Retrieved 2012-03-01. 
  6. ^ "The Methiopropamine thread.". http://www.bluelight.ru/vb/showpost.php?p=9165913&postcount=142. Retrieved 2011-05-08. 
  7. ^ a b "Erowid Experience Vaults: Methiopropamine - For Study". 2011-05-23. Archived from the original on 2011-08-31. http://www.erowid.org/experiences/exp.php?ID=92674. Retrieved 2012-02-29. 
  8. ^ "The Methiopropamine Thread". 2011-07-03. http://www.bluelight.ru/vb/threads/544266-The-Methiopropamine-N-methyl-1-(thiophen-2-yl)propan-2-amine-Thread?p=9793181&viewfull=1#post9793181. Retrieved 2012-02-29. 
  9. ^ "The Methiopropamine Thread". 2011-02-20. http://www.bluelight.ru/vb/threads/544266-The-Methiopropamine-N-methyl-1-(thiophen-2-yl)propan-2-amine-Thread?p=9365326&viewfull=1#post9365326. Retrieved 2012-02-29. 
  10. ^ "The Methiopropamine Thread". 2010-12-26. http://www.bluelight.ru/vb/threads/544266-The-Methiopropamine-N-methyl-1-(thiophen-2-yl)propan-2-amine-Thread/page4. Retrieved 2012-02-29. 
  11. ^ "Methiopropamine - Dose". Erowid. 2011-07-05. http://www.erowid.org/chemicals/methiopropamine/methiopropamine_dose.shtml. Retrieved 2012-03-01. 


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