NAD+ kinase: Definition from Answers.com

Gene Ontology
Molecular function	• nucleotide binding • NAD+ kinase activity • NAD+ kinase activity • protein binding • ATP binding • transferase activity • metal ion binding
Cellular component	• cytosol • cytosol
Biological process	• vitamin metabolic process • water-soluble vitamin metabolic process • metabolic process • phosphorylation • NAD metabolic process • ATP metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
1.68 – 1.71 Mb

Chr 4:
154.94 – 154.97 Mb

PubMed search

[1]

[2]

NAD⁺ kinase (EC 2.7.1.23, NADK) is an enzyme that converts nicotinamide adenine dinucleotide (NAD⁺) into NADP⁺, through phosphorylating the NAD⁺ coenzyme.^[2] NADP⁺ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.^[3] The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined.^[1]

In humans, NAD⁺ kinase is encoded by the NADK gene.^[4]

Contents

1 Reaction
2 See also
3 References
4 Further reading
5 External links

Reaction

ATP + NAD⁺ $\rightleftharpoons$ ADP + NADP⁺

References

^ ^a ^b PDB 1SUW; Liu J, Lou Y, Yokota H, Adams PD, Kim R, Kim SH (November 2005). "Crystal structures of an NAD kinase from Archaeoglobus fulgidus in complex with ATP, NAD, or NADP". J. Mol. Biol. 354 (2): 289–303. doi:10.1016/j.jmb.2005.09.026. PMID 16242716.
^ Magni G, Orsomando G, Raffaelli N (2006). "Structural and functional properties of NAD kinase, a key enzyme in NADP biosynthesis". Mini reviews in medicinal chemistry 6 (7): 739–46. doi:10.2174/138955706777698688. PMID 16842123.
^ Pollak N, Dölle C, Ziegler M (2007). "The power to reduce: pyridine nucleotides – small molecules with a multitude of functions". Biochem. J. 402 (2): 205–18. doi:10.1042/BJ20061638. PMC 1798440. PMID 17295611. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1798440.
^ Lerner F, Niere M, Ludwig A, Ziegler M (October 2001). "Structural and functional characterization of human NAD kinase". Biochem. Biophys. Res. Commun. 288 (1): 69–74. doi:10.1006/bbrc.2001.5735. PMID 11594753.

External links

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD⁺ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor	Phosphoglycerate · Aspartate

2.7.3: N acceptor	Creatine

2.7.4: PO₄ acceptor	Phosphomevalonate · Adenylate · Nucleoside-diphosphate · Uridylate · Guanylate

2.7.6: diphosphotransferase
(P₂O₇)

Ribose-phosphate diphosphokinase · Thiamine pyrophosphokinase

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme RNA-directed DNA polymerase: Reverse transcriptase (Telomerase) DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase	RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase PNPase

Phosphorolytic
3' to 5' exoribonuclease

RNase PH · PNPase

Uridylyltransferase

Glucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

Recombinase (Integrase) · Transposase

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase

Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases

2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases

2.7.13: protein-histidine	Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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NAD+ kinase

NAD+ kinase

NAD+ kinase

Reaction

See also

References

Further reading

External links

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