Nalorphine: Information from Answers.com


Nalorphine
Systematic (IUPAC) name
(5α,6α)-17-allyl- 7,8-didehydro- 4,5-epoxymorphinan- 3,6-diol
Identifiers
CAS number	62-67-9
ATC code	V03AB02
PubChem	5284595
Chemical data
Formula	C₁₉H₂₁N O₃
Mol. mass	311.375 g/mol
Synonyms	(−)−(5R,6S)-9α-allyl- 4,5-epoxymorphin- 7-en- 3,6-diol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?
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Nalorphine (INN, also known as N-allyl-normorphine) trade names Lethidrone and Nalline. Nalorphine acts at two opioid receptors, at the mu receptor it has antagonistic effects and at the kappa receptors it exerts agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.^[1]

References

^ [http://www.time.com/time/magazine/article/0,9171,808859,00.html "Medicine: Drug Detector"], Time, Dec. 24, 1956

Antidotes (V03AB)

Nervous system


Nerve agent / Organophosphate poisoning	Atropine^# · Biperiden · Diazepam^# · Oximes (Pralidoxime, Obidoxime) · see also Cholinesterase

Opioid overdose	Diprenorphine · Doxapram · Nalorphine · Naloxone^# · Naltrexone · Nalmefene

Barbiturate overdose	Bemegride · Ethamivan

Benzodiazepine overdose	Cyprodenate · Flumazenil

GHB overdose	Physostigmine · SCH-50911

Reversal of neuromuscular blockade	Sugammadex

Cardiovascular

Heparin	Protamine^#

Digoxin toxicity	Digoxin Immune Fab

Beta blocker	Glucagon

Other

Methanol / Ethylene glycol poisoning	Ethanol · Fomepizole

Paracetamol toxicity (Acetaminophen)	Acetylcysteine^# · Glutathione · Methionine^#

Arsenic poisoning	Dimercaprol^# · Succimer

Cyanide poisoning	nitrite (Amyl nitrite, Sodium nitrite^#) · Sodium thiosulfate^# · 4-Dimethylaminophenol · Hydroxocobalamin

Toxic metals (cadmium, mercury, lead, thallium)	Edetates · Dimercaprol^# · Prussian blue

Hydrofluoric acid	Calcium gluconate^#

Other	Prednisolone and promethazine · oxidizing agent (potassium permanganate) · iodine-131 (Potassium iodide) · Methylthioninium chloride^#

Emetic

Ipecacuanha (Syrup of ipecac) · Copper sulfate

^#WHO-EM. ^‡Withdrawn from market. CLINICAL TRIALS: ^†Phase III. ^§Never to phase III

Opioids (N02A)

Opium
derivatives

Whole Opium
Preparations

Compote/Kompot/Polish Heroin · Diascordium · B & O Supprettes · Dover's powder · Laudanum · Mithridate · Opium · Paregoric · Concentrate of Poppy Straw (CPS) · Poppy tea · Smoking Opium · Theriac

Natural Opiates

Opium Alkaloids see also: Components of Opium	Codeine · Morphine · Oripavine · Pseudomorphine · Thebaine

Alkaloid Salts Mixtures	Pantopon · Papaveretum (Omnopon) · Tetrapon

Semisynthetics

Morphine Family	14-Hydroxymorphine · 14β-Hydroxymorphine · 14β-Hydroxymorphone · 2,4-Dinitrophenylmorphine · 6-Methyldihydromorphine · 6-Methylenedihydrodesoxymorphine · 6-Acetyldihydromorphine/6-Monoacetyldihydromorphine · Acetyldihydromorphine · Azidomorphine · Chlornaltrexamine · Chloromorphide · Dihydrodesoxymorphine (Desomorphine) · Dihydromorphine · Ethyldihydromorphine · Hydromorphinol · Methyldesorphine · N-Phenethylnormorphine · Pseudomorphine

3,6 Diesters of Morphine	Diacetyldihydromorphine (Dihydroheroin) · Dibenzoylmorphine · Dibutanoylmorphine · Dipropanoylmorphine · Disalicyloylmorphine · Heroin (Diacetylmorphine) · Heroin-7,8-Oxide · Nicomorphine

Codeine-Dionine Family	14-Hydroxydihydrocodeine · Acetylcodeine · Benzylmorphine · Codeine methylbromide · Desocodeine · Methyldihydromorphine (Dihydroheterocodeine) · Ethylmorphine (Dionine) · Heterocodeine · Isocodeine · Morpholinylethylmorphine (Pholcodine) · Myrophine · Nalodeine · Transisocodeine

Morphinones	14-Ethoxymetopon · 14-Methoxymetopon · 14β-Hydroxymorphone · 14-O-Methyloxymorphone · 14-phenylpropoxy-5-methyl-hydromorphone · 14-Phenylpropoxymetopon · 7-Spiroindanyloxymorphone · 8,14-Dihydroxydihydromorphinone · Acetylmorphone · Ethyldihydromorphinone · Hydromorphinone · Hydromorphone · Hydroxycodeine · Methyldihydromorphinone · Metopon · Morphinol · Morphinone · N-Phenethyl-14-ethoxymetopon · Oxymorphol · Oxymorphone · Pentamorphone · Semorphone

Codeinones	1-carboxy-14-hydroxydihydrocodeinone · 1-carbethoxy-14-hydroxydihydrocodeinone · Thebacon (Acetyldihydrocodeinone / Dihydrocodeinone enol acetate) · Codeinone · Codorphone · Codoxime · Hydrocodone · Monodihydrocodeineone · Oxycodone

Dihydrocodeine Series	14-hydroxydihydrocodeine · Acetyldihydrocodeine · Dihydrocodeine · Dihydrodesoxycodeine/Desocodeine · Dihydroisocodeine · Nicocodeine · Nicodicodeine

Nitrogen Morphine Derivatives	Codeine-N-Oxide · Heroin-N-Oxide · Hydromorphone-N-Oxide · Morphine-N-Oxide

Hydrazones	Hydromorphazone · Morphazone · Oxymorphazone

Others	α-chlorocodide · Pholcodine

Active Opiate
Metabolites

Codeine-N-Oxide (Genocodeine) · Dihydromorphine-6-glucuronide · Hydromorphone-N-Oxide · Heroin-7,8-Oxide · Morphine-6-glucuronide · 6-Acetylmorphine · Morphine-N-Oxide (Genomorphine) · Naltrexol · Norcodeine · Normorphine

Morphinans

Morphinan Series	4-chlorophenylpyridomorphinan · Cyclorphan · Dextro-3-hydroxy-N-allylmorphinan · Dimemorfan · Levargorphan · Levallorphan · Levorphanol · Levorphan · Levophenacylmorphan · Levomethorphan · Norlevorphanol · N-Methylmorphinan · Oxilorphan · Phenomorphan · Methorphan / Racemethorphan · Morphanol / Racemorphanol · Ro4-1539 · Stephodeline · Xorphanol

Others	1-Nitroaknadinine · 14-episinomenine · 5,6-Dihydronorsalutaridine · 6-Ketonalbuphine · Aknadinine · Butorphanol · Cephakicine · Cephasamine · Cyprodime · Drotebanol · Fenfangjine G · Nalbuphine · Sinococuline · Sinomenine (Cocculine) · Tannagine

Benzomorphans

5,9-DEHB · Alazocine · Anazocine · Bremazocine · Cogazocine · Cyclazocine · Dezocine · Eptazocine · Etazocine · Ethylketocyclazocine · Fluorophen · Ketazocine · Metazocine · Pentazocine · Phenazocine · Quadazocine · Thiazocine · Tonazocine · Volazocine · Zenazocine

4-Phenylpiperidines

Pethidines (Meperidines)	Allylnorpethidine · Anileridine · Benzethidine · Carperidine · Difenoxin · Diphenoxylate · Etoxeridine (Carbetidine) · Furethidine · Hydroxypethidine (Bemidone) · Hydroxymethoxypethidine · Morpheridine · Oxpheneridine (Carbamethidine) · Meperidine-N-Oxide · Pethidine (Meperidine) · Pethidine Intermediate A · Pethidine Intermediate B (Norpethidine) · Pethidine Intermediate C (Pethidinic Acid) · Pheneridine · Phenoperidine · Piminodine · Properidine (Ipropethidine) · Sameridine

Prodines	Allylprodine · Isopromedol · Meprodine (α-meprodine / β-meprodine) · MPPP (Desmethylprodine) · PEPAP · Prodine (α-prodine / β-prodine) · Prosidol · Trimeperidine (Promedol)

Ketobemidones	Acetoxyketobemidone · Droxypropine · Ketobemidone · Methylketobemidone · Propylketobemidone

Others	Alvimopan · Loperamide · Picenadol

Open Chain
Opioids

Amidones	Dextromethadone · Dextroisomethadone · Dipipanone · Hexalgon (Norpipanone) · Isomethadone · Levoisomethadone · Levomethadone · Methadone · Methadone intermediate · Normethadone · Norpipanone · Phenadoxone (Heptazone) · Pipidone

Methadols	Dimepheptanol (Racemethadol) · Levacetylmethadol · Levomethadyl acetate (Acetylmethadol) · Noracetylmethadol

Moramides	Dextromoramide · Levomoramide · Moramide intermediate · Racemoramide

Thiambutenes	Diethylthiambutene · Dimethylthiambutene · Ethylmethylthiambutene · Piperidylthiambutene · Pyrrolidinylthiambutene · Thiambutene · Tipepidine

Phenalkoxams	Dextropropoxyphene (Propoxyphene) · Dimenoxadol · Dioxaphetyl Butyrate · Levopropoxyphene · Norpropoxyphene

Ampromides	Diampromide · Phenampromide · Propiram

Others	IC-26 · Isoaminile · Lefetamine · R-4066

Anilidopiperidines

3-Allylfentanyl · 3-Methylfentanyl · 3-Methylthiofentanyl · Alfentanil · α-methylacetylfentanyl · α-methylfentanyl · α-methylthiofentanyl · Benzylfentanyl · β-hydroxyfentanyl · β-hydroxythiofentanyl · β-methylfentanyl · Brifentanil · Carfentanil · Fentanyl · Lofentanil · Mirfentanil · Ocfentanil · Ohmefentanyl · Parafluorofentanyl · Phenaridine · Remifentanil · Sufentanil · Thenylfentanyl · Thiofentanyl · Trefentanil

Oripavine
derivatives

6,14-Endoethenotetrahydrooripavine · 7-PET · Acetorphine · Alletorphine · BU-48 · Buprenorphine · Butorphine · Cyprenorphine · Dihydroetorphine · Diprenorphine (M5050) · Etorphine · 18,19-Dehydrobuprenorphine (HS-599) · N-cyclopropylmethyl-noretorphine · Nepenthone · Norbuprenorphine · Thevinone · Thienorphine

Phenazepines

Ethoheptazine · Meptazinol · Metheptazine · Metethoheptazine · Proheptazine

Pirinitramides

Bezitramide · Piritramide

Benzimidazoles

Clonitazene · Etonitazene · Nitazene

Indoles

18-MC · 7-Acetoxymitragynine · 7-Hydroxymitragynine · Akuammidine · Akuammine · Eseroline · Hodgkinsine · Ibogaine · Mitragynine · Noribogaine · Pericine · ψ-Akuammigine

Diphenylmethylpiperazines

BW373U86 · DPI-221 · DPI-287 · DPI-3290 · SNC-80

Opioid peptides
see also: The Opioid Peptides

Casomorphin · DADLE · DALDA · DAMGO · Dermenkephalin · Dermorphin · Deltorphin · DPDPE · Dynorphin · Endomorphin · Endorphin · Enkephalin · Gliadorphin · Morphiceptin · Nociceptin · Octreotide · Opiorphin · Rubiscolin · TRIMU 5

Others

3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane · Azaprocin · BDPC · Bisnortilidine · BRL-52537 · C-8813 · Ciramadol · Enadoline · Faxeladol · Herkinorin · J-113,397 · JTC-801 · Methopholine · NNC 63-0532 · Nortilidine · O-Desmethyltramadol · Phenadone · Prodilidine · Profadol · Ro64-6198 · Salvinorin A · SB-612,111 · SC-17599 · RWJ-394,674 · TAN-67 · Tapentadol · Tecodine · Tifluadom · Tilidine · Tramadol · Viminol · W-18 ·

Opioid Antagonists
&
Inverse-Agonists

5'-Guanidinonaltrindole · β-Funaltrexamine · 6β-Naltrexol · Alvimopan · Amiphenazole · Binaltorphimine · Chlornaltrexamine · Clocinnamox · Cyclazocine · Cyprodime · Diprenorphine (M5050) · Fedotozine · JDTic · Levallorphan · Methocinnamox · Methylnaltrexone · Nalfurafine · Nalmefene · Nalmexone · Naloxazone · Naloxonazine · Naloxone · Naloxone benzoylhydrazone · Nalorphine · Naltrexone · Naltriben · Naltrindole · Norbinaltorphimine · Oxilorphan · S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)

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