Nalorphine

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Nalorphine

Systematic (IUPAC) name
(5α,6α)-17-allyl- 7,8-didehydro- 4,5-epoxymorphinan- 3,6-diol
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	62-67-9^Y
ATC code	V03AB02
PubChem	CID 5284595
IUPHAR ligand	1629
ChemSpider	4447643^Y
UNII	U59WB2WRY2^N
ChEMBL	CHEMBL415284^N
Synonyms	(−)−(5R,6S)-9α-allyl- 4,5-epoxymorphin- 7-en- 3,6-diol
Chemical data
Formula	C₁₉H₂₁N O₃
Mol. mass	311.375 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1^Y Key:UIQMVEYFGZJHCZ-SSTWWWIQSA-N^Y
N (what is this?) (verify)

Nalorphine (INN; Lethidrone, Nalline), also known as N-allyl-normorphine, is a mixed opioid agonist-antagonist. It acts at two opioid receptors, at the mu receptor it has antagonistic effects and at the kappa receptors it exerts agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.^[1]

References

^ "Medicine: Drug Detector", Time, Dec. 24, 1956

Antidotes (V03AB)

Nervous system


Nerve agent / Organophosphate poisoning	Atropine^# Biperiden Diazepam^# Oximes (Pralidoxime Obidoxime) see also Cholinesterase

Opioid overdose	Diprenorphine Doxapram Nalorphine Naloxone^# Naltrexone Nalmefene

Barbiturate overdose	Bemegride Ethamivan

Benzodiazepine overdose	Cyprodenate Flumazenil

GHB overdose	Physostigmine SCH-50911

Reversal of neuromuscular blockade	Sugammadex

Cardiovascular

Heparin	Protamine^#

Digoxin toxicity	Digoxin Immune Fab

Beta blocker	Glucagon

Other

Methanol / Ethylene glycol poisoning	Ethanol Fomepizole

Paracetamol toxicity (Acetaminophen)	Acetylcysteine^# Glutathione Methionine^#

Arsenic poisoning	Dimercaprol^# Succimer

Cyanide poisoning	nitrite (Amyl nitrite Sodium nitrite^#) Sodium thiosulfate^# 4-Dimethylaminophenol Hydroxocobalamin

Toxic metals (cadmium mercury lead thallium)	Edetates Dimercaprol^# Prussian blue^#

Hydrofluoric acid	Calcium gluconate^#

Other	Prednisolone/promethazine oxidizing agent (potassium permanganate) iodine-131 (Potassium iodide) Methylthioninium chloride^#

Emetic

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

M: TOX

gen / txn

pto

ant

Opioids

Opium and
poppy straw
derivatives

Crude opiate extracts/
whole opium products

Natural opiates

Opium alkaloids see also: Components of opium	Codeine Morphine Oripavine Pseudomorphine Thebaine

Alkaloid salts mixtures	Pantopon Papaveretum (Omnopon)

Semisynthetics
including
Bentley compounds

Morphine family	2,4-Dinitrophenylmorphine 6-Methylenedihydrodesoxymorphine Azidomorphine Chlornaltrexamine Dihydrodesoxymorphine (Desomorphine) Dihydromorphine Hydromorphinol Methyldesorphine N-Phenethylnormorphine RAM-378

3,6-diesters of morphine	Acetylpropionylmorphine Diacetyldihydromorphine (Dihydroheroin, Acetylmorphinol) Dibenzoylmorphine Dipropanoylmorphine Heroin (Diacetylmorphine) Nicomorphine

Codeine-dionine family	6-Monoacetylcodeine Benzylmorphine Codeine methylbromide Methyldihydromorphine (Dihydroheterocodeine) Ethylmorphine (Dionine) Heterocodeine Morpholinylethylmorphine (Pholcodine) Myrophine

Morphinones and morphols	14-Cinnamoyloxycodeinone 14-Ethoxymetopon 14-Methoxymetopon 14-Phenylpropoxymetopon 6-Methylenedihydrodesoxymorphine 7-Spiroindanyloxymorphone Acetylmorphone Codeinone Codorphone Codoxime IBNtxA Thebacon (Acetyldihydrocodeinone / Dihydrocodeinone enol acetate) Hydrocodone Hydromorphone Metopon Morphinone N-Phenethyl-14-ethoxymetopon Nalmexone Oxycodone Oxymorphol Oxymorphone Pentamorphone Semorphone

Morphides	Chloromorphide

Dihydrocodeine series	14-hydroxydihydrocodeine Acetyldihydrocodeine Dihydrocodeine Nicocodeine Nicodicodeine

Nitrogen morphine derivatives	Morphine-N-Oxide

Hydrazones	Oxymorphazone

Halogenated morphine derivatives	1-Iodomorphine

Active opiate
metabolites

Morphinans

Benzomorphans

4-Phenylpiperidines

Pethidines (Meperidines)	4-Fluoromeperidine Allylnorpethidine Anileridine Benzethidine Carperidine Difenoxin Diphenoxylate Etoxeridine (Carbetidine) Furethidine Hydroxypethidine (Bemidone) Morpheridine Oxpheneridine (Carbamethidine) Pethidine (Meperidine) Pethidine Intermediate A Pethidine Intermediate B (Norpethidine) Pethidine Intermediate C (Pethidinic Acid) Pheneridine Phenoperidine Piminodine Properidine (Ipropethidine) Sameridine

Prodines	Allylprodine Meprodine (α-meprodine / β-meprodine) MPPP (Desmethylprodine) PEPAP Prodine (α-prodine / β-prodine) Prosidol Trimeperidine (Promedol)

Ketobemidones	Acetoxyketobemidone Droxypropine Ketobemidone Methylketobemidone Propylketobemidone

Others	Alvimopan Loperamide Picenadol

Open chain
opioids

Amidones	Dipipanone Methadone Normethadone Norpipanone Phenadoxone (Heptazone)

Methadols	Alphacetylmethadol Dimepheptanol (Racemethadol) Levacetylmethadol Noracymethadol

Moramides	Desmethylmoramide Dextromoramide Levomoramide Moramide/Racemoramide

Thiambutenes	Diethylthiambutene Dimethylthiambutene Ethylmethylthiambutene Piperidylthiambutene Pyrrolidinylthiambutene Thiambutene Tipepidine

Phenalkoxams	Dextropropoxyphene (Propoxyphene) Dimenoxadol Dioxaphetyl Butyrate Levopropoxyphene Norpropoxyphene

Ampromides	Diampromide Phenampromide Propiram

Others	IC-26 Isoaminile Lefetamine R-4066

Anilidopiperidines

Oripavine
derivatives

Phenazepanes

Pirinitramides

Benzimidazoles

Indoles

Diphenylmethylpiperazines

Opioid peptides
see also: Opioid neuropeptides

Others

Opioid antagonists &
inverse agonists

Uncategorized opioids

Alimadol
Anilopam
Asimadoline
Fedotozine
Nalfurafine
Nalorphine
Nalorphine dinicotinate
SoRI-9409

List of opioids

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