Naltriben
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Naltriben
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| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 111555-58-9 |
| ATC code | None |
| PubChem | CID 5486827 |
| IUPHAR ligand | 1640 |
| ChemSpider | 4589081  |
| ChEMBL | CHEMBL100940 |
| Chemical data | |
| Formula | C26H25NO4 |
| Mol. mass | 415.480 g/mol |
| SMILES | eMolecules & PubChem |
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Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.[1] It also acts as a κ-opioid agonist at high doses.[2]
References
- ^ Sofuoglu M, Portoghese PS, Takemori AE. Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. 1991 May;257(2):676-80. PMID 1851833
- ^ Stewart PE, Holper EM, Hammond DL. Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes. Life Sciences. 1994;55(4):PL79-84. PMID 8028443
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