Nebulette
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Nebulette
| nebulette | |
|---|---|
| Identifiers | |
| Symbol | NEBL |
| Entrez | 10529 |
| HUGO | 16932 |
| OMIM | 605491 |
| RefSeq | NM_006393 |
| UniProt | O76041 |
| Other data | |
| Locus | Chr. 10 p12 |
Nebulette is an isoform of the protein nebulin. While nebulin (600-900 kDa) is expressed preferentially in skeletal muscle, nebulette (107 kDa) is expressed in cardiac muscle. Nebulette was identified in 1995 by Moncman and Wang using primary cultures of chicken embryonic cardiomyocytes by immunoprecipitations with certain anti-nebulin monoclonal antibodies.[1] Normal expression of nebulette is essential for the assembly and contractile function of myofibrils.[2]
References
- ^ Moncman & Wang; Wang, K (1995). "Nebulette: a 107 kD nebulin-like protein in cardiac muscle". Cell Motil Cytoskeleton 32 (3): 205–25. doi:10.1002/cm.970320305. PMID 8581976.
- ^ Moncman & Wang; Wang, K (2002). "Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function". Exp Cell Res 273 (2): 204–18. doi:10.1006/excr.2001.5423. PMID 11822876.
External links
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