Neddylation
Oxford Dictionary of Biochemistry:
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neddylation
the process whereby Nedd-8 (or Rub 1 of yeast), a ubiquitin-like protein conjugate to some proteins to target them for degradation by proteasomes or for deneddylation by COP signalosomes. It is important in controlling the auxin response pathway in plants.
| nectin-1, nectary, necrotizing encephalopathy | |
| negative, negative chromatography, negative control |
Wikipedia on Answers.com:
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Neddylation
Neddylation is the process by which the ubiquitin like protein Nedd8 is conjugated to its target proteins. This process is analogous to ubiquitination, although relies on its own E1 and E2 enzymes. No Nedd8-specific E3 has yet been identified and it is possible that the Neddylation system relies on E3 ligases with dual specificity.
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Contents
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NEDD8
Neural-precursor-cell-expressed developmentally down-regulated 8 is involved in the regulation of cell growth, viability and development.
Neddylation process
http://www.nature.com/embor/journal/v9/n10/images/embor2008183-f1.jpg
Disease association
Neddylation is involved in the pathogenesis of Alzheimer's Disease where its activation appears to drive neurons into apoptosis by initiating cell cycle reentry.
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Oxford Dictionary of Biochemistry
Oxford University Press. Oxford Dictionary of Biochemistry and Molecular Biology © 1997, 2000, 2006 All rights reserved.
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