Nedocromil
Drug Info:
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Nedocromil
Brand names: Alocril®Tilade®
Chemical formula:
- Drug Forms:
- Nedocromil Sodium Pressurized inhalation, suspension (below)
- Nedocromil Sodium Ophthalmic drops, solution
- Espa�ol:
- Nedocromil Sódico, Inhalación presurizada, suspensión
- Nedocromil Sódico, Gotas oftálmicas, solución
Nedocromil Sodium Pressurized inhalation, suspension
What is this medicine?
NEDOCROMIL (ne doe KROE mil) helps reduce inflammation. This medicine is used to treat the symptoms of asthma. Never use this medicine to treat an acute asthma attack.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
•heart disease
•irregular heartbeats
•an unusual or allergic reaction to nedocromil, fluorocarbons, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
How should I use this medicine?
Inhale this medicine through the mouth. Follow the directions on your prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice. Make sure that you are using your inhaler correctly. Ask you doctor or health care provider if you have any questions.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years of age for selected conditions, precautions do apply.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.What may interact with this medicine?
Interactions are not expected.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress. Tell your doctor if your symptoms do not improve. If your symptoms get worse or if you need your short-acting inhalers more often, call your doctor right away.
Do not get this medicine in your eyes. It can cause irritation.
If you get a bitter or unpleasant taste in your mouth, gargle or rinse your mouth after you use this medicine.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breathing difficulty, wheezing
•fever, infection
•joint pain
•tremor
•unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•bitter taste
•cough
•headache
•nausea, vomiting
•runny nose
•stomach upset, pain
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
Keep out of the reach of children.
Store between 2 and 30 degrees C (36 and 86 degrees F). Do not freeze. Do not puncture or overheat the container. Keep track of the number of doses used. Throw away the inhaler after 104 inhalations or after the expiration date, whichever comes first.
Last updated: 7/1/2002
Important Disclaimer: The drug information provided here is for educational purposes only. It is intended to supplement, not substitute for, the diagnosis, treatment and advice of a medical professional. This drug information does not cover all possible uses, precautions, side effects and interactions. It should not be construed to indicate that this or any drug is safe for you. Consult your medical professional for guidance before using any prescription or over the counter drugs.
Wikipedia on Answers.com:
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Nedocromil
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|---|---|
| Systematic (IUPAC) name | |
| 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid | |
| Clinical data | |
| Trade names | Alocril |
| AHFS/Drugs.com | monograph |
| MedlinePlus | a601243 |
| Pregnancy cat. | ? |
| Legal status | POM (UK) ℞-only (US) |
| Routes | Inhalation and eye drops |
| Pharmacokinetic data | |
| Protein binding | 89% |
| Metabolism | not metabolized |
| Half-life | ~3.3 hours |
| Excretion | excreted unchanged |
| Identifiers | |
| CAS number | 69049-73-6  |
| ATC code | R01AC07 R03BC03, S01GX04 |
| PubChem | CID 50294 |
| DrugBank | DB00716 |
| ChemSpider | 45608 |
| UNII | 0B535E0BN0 |
| KEGG | D05129 |
| ChEBI | CHEBI:7492 |
| ChEMBL | CHEMBL746 |
| Chemical data | |
| Formula | C19H17NO7 |
| Mol. mass | 371.341 g/mol |
| SMILES | eMolecules & PubChem |
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 (what is this?) (verify) |
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Nedocromil sodium is a medication used to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade (although its effects in this form are far less than those in albuterol or other well-known inhaler medications) and as an eye drop under the brand name Alocril. Liquid preparations are available in the UK under the name Rapitil for use for allergic eye reactions.[1]
Nedocromil is classified as a cromone. Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008.[2]
References
- ^ "Nedocromil eye drops" (in English). 2007-02-02. http://www.patient.co.uk/showdoc/30003772. Retrieved 2009-08-04.
- ^ http://www.fda.gov/downloads/Drugs/DrugSafety/DrugShortages/ucm089433.pdf
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