NEFA

Oxford Dictionary of Biochemistry:

NEFA

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abbr. for nonesterified fatty acid. Compare FFA.

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NEFA (drug)

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NEFA (drug)

Systematic (IUPAC) name
(4aR,9aS)-N-Ethyl-4,4a,9,9a-tetrahydro-1H-fluoren-4a-amine
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
Chemical data
Formula	C₁₅H₁₉N
Mol. mass	213.3181 g/mol
Y(what is this?) (drug) (verify)

NEFA is a moderate affinity NMDA antagonist (IC₅₀ = 0.51 μM). It is a structural analog of phencyclidine.^[1]

References

^ Dilmore JG, Johnson JW (1998). "Open channel block and alteration of N-methyl-D-aspartic acid receptor gating by an analog of phencyclidine". Biophysical Journal 75 (4): 1801–16. doi:10.1016/S0006-3495(98)77622-2. PMC 1299852. PMID 9746522. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1299852.

Hallucinogens

Psychedelics
5-HT_2AR agonists

Phenethylamines: Aleph
2C-B
2C-B-Dragonfly
2C-B-FLY
2C-C-FLY
2C-D-FLY
2C-E-FLY
2C-I-FLY
2CBFly-NBOMe
2C-T-7-FLY
2C-C
2C-C-NBOMe
2C-CN-NBOMe
2C-D
2CD-5EtO
2C-D-NBOMe
2C-E
2C-EF
2C-E-NBOMe
2C-F
2C-F-NBOMe
2C-G
2C-G-NBOMe
2C-H-NBOMe
2C-I
2C-N
2C-N-NBOMe
2C-O
2C-O-4
2C-P
2C-T
2C-T-2
2C-T-4
2C-T-4-NBOMe
2C-T-7
2C-T-7-NBOH
2C-T-8
2C-T-9
2C-T-13
2C-T-15
2C-T-17
2C-T-21
2C-TFM
2C-TFM-NBOMe
2C-YN
2CBCB-NBOMe
25B-NBOMe
25I-NBMD
25I-NBOH
25I-NBOMe
3C-E
3C-P
5-APB
5-APDB
6-APB
6-APDB
Br-DFLY
DESOXY
DMMDA
DMMDA-2
DOB
DOB-FLY
DOM-FLY
DOC
DOEF
DOET
DOF
DOI
DOM
DON
DOPR
DOTFM
Escaline
Ganesha
HOT-2
HOT-7
HOT-17
IAP
Isoproscaline
Jimscaline
Lophophine
MDA
MDEA
MDMA
MMA
MMDA
MMDA-2
MMDA-3a
MMDMA
Macromerine
Mescaline
Methallylescaline
NBOMe-mescaline
Proscaline
TCB-2
TFMFly
TMA;

Piperazines: pFPP
TMFPP;

Tryptamines: 1-Methyl-5-methoxy-diisopropyltryptamine
2,N,N-TMT
4,N,N-TMT
4-HO-5-MeO-DMT
4-Acetoxy-DET
4-Acetoxy-DIPT
4-Acetoxy-DMT
4-Acetoxy-DPT
4-Acetoxy-MiPT
4-HO-DPT
4-HO-MET
4-Propionyloxy-DMT
4-HO-MPMI
5-Me-MIPT
5-N,N-TMT
5-AcO-DMT
5-MeO-2,N,N-TMT
5-MeO-4,N,N-TMT
5-MeO-α,N,N-TMT
5-MeO-α-ET
5-MeO-α-MT
5-MeO-DALT
5-MeO-DET
5-MeO-DIPT
5-MeO-DMT
5-MeO-DPT
5-MeO-EiPT
5-MeO-MET
5-MeO-MIPT
5-MeO-MPMI
7,N,N-TMT
α,N,N-TMT
α-ET
α-MT
AL-37350A
Baeocystin
Bufotenin
DALT
DBT
DCPT
DET
DIPT
DMT
DPT
EiPT
Ethocin
Ethocybin
Iprocin
MET
Miprocin
MIPT
Norbaeocystin
PiPT
Psilocin
Psilocybin;

Dissociatives
NMDAR antagonists

Deliriants
mAChR antagonists

Miscellaneous

Cannabinoids CB₁R agonists	Cannabinol CP-47,497 CP-55,244 CP-55,940 DMHP HU-210 JWH-018 JWH-030 JWH-073 JWH-081 JWH-200 JWH-250 Nabilone Nabitan Nantradol Parahexyl THC (Dronabinol) WIN-55,212-2

D₂R agonists	Apomorphine Bromocriptine Cabergoline Lisuride Memantine Pergolide Piribedil Pramipexole Ropinirole Rotigotine * Also indirect D₂ agonists such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, methamphetamine), and precursors (levodopa).

GABA_AR agonists	Eszopiclone Gaboxadol Ibotenic Acid Muscimol Zolpidem Zopiclone

Inhalants Mixed MOA	Butane Chloroform Diethyl Ether (Ether) Enflurane Freon Gasoline (Petrol) Kerosene (Paraffin) Propane Toluene

κOR agonists	2-EMSB 2-MMSB Alazocine Bremazocine Butorphanol Cyclazocine Cyprenorphine Dextrallorphan Dezocine Enadoline Herkinorin HZ-2 Ibogaine Ketazocine Metazocine Nalbuphine Nalorphine Noribogaine Pentazocine Phenazocine Salvinorin A Spiradoline Tifluadom U-50,488 U-69,593

σR agonists	Dextrallorphan Dextromethorphan Dextrorphan Noscapine (Narcotine)

Others	Efavirenz Glaucine Isoaminile

Glutamatergics

Ionotropic

AMPA	Agonists: 5-Fluorowillardiine • AMPA • Domoic acid • Quisqualic acid; Positive allosteric modulators: Aniracetam • Cyclothiazide • CX-516 • CX-546 • CX-614 • CX-691 • CX-717 • Diazoxide • HCTZ • IDRA-21 • LY-392,098 • LY-404,187 • LY-451,395 • LY-451,646 • LY-503,430 • Oxiracetam • PEPA • Piracetam • Pramiracetam • S-18986 • Sunifiram • Unifiram Antagonists: ATPO • Barbiturates • Caroverine • CNQX • DNQX • GYKI-52466 • NBQX • Perampanel • Talampanel • Tezampanel • Topiramate; Negative allosteric modulators: GYKI-53,655

NMDA	Agonists: Glutamate/acite site competitive agonists: Aspartate • Glutamate • Homoquinolinic acid • Ibotenic acid • NMDA • Quinolinic acid • Tetrazolylglycine; Glycine site agonists: ACBD • ACPC • ACPD • Alanine • CCG • Cycloserine • DHPG • Fluoroalanine • Glycine • HA-966 • L-687,414 • Milacemide • Sarcosine • Serine • Tetrazolylglycine; Polyamine site agonists: Acamprosate • Spermidine • Spermine Antagonists: Competitive antagonists: AP5 (APV) • AP7 • CGP-37849 • CGP-39551 • CGP-39653 • CGP-40116 • CGS-19755 • CPP • LY-233,053 • LY-235,959 • LY-274,614 • MDL-100,453 • Midafotel (d-CPPene) • NPC-12,626 • NPC-17,742 • PBPD • PEAQX • Perzinfotel • PPDA • SDZ-220581 • Selfotel; Noncompetitive antagonists: ARR-15,896 • Caroverine • Dexanabinol • FPL-12495 • FR-115,427 • Hodgkinsine • Magnesium • MDL-27,266 • NPS-1506 • Psychotridine • Zinc; Uncompetitive pore blockers: 2-MDP • 3-MeO-PCP • 8A-PDHQ • Alaproclate • Amantadine • Aptiganel • ARL-12,495 • ARL-15,896-AR • ARL-16,247 • Budipine • Delucemine • Dexoxadrol • Dextrallorphan • Dieticyclidine • Dizocilpine • Endopsychosin • Esketamine • Etoxadrol • Eticyclidine • Gacyclidine • Ibogaine • Indantadol • Ketamine • Ketobemidone • Loperamide • Memantine • Meperidine (Pethidine) • Methadone • Methorphan (Dextromethorphan, Levomethorphan) • Methoxetamine • Milnacipran • Morphanol (Dextrorphan, Levorphanol) • NEFA • Neramexane • Nitrous oxide • Noribogaine • Orphenadrine • PCPr • Phencyclamine • Phencyclidine • Propoxyphene • Remacemide • Rhynchophylline • Riluzole • Rimantadine • Rolicyclidine • Sabeluzole • Tenocyclidine • Tiletamine • Tramadol • Xenon; Glycine site antagonists: ACEA-1021 • ACEA-1328 • ACPC • Carisoprodol • CGP-39653 • CKA • DCKA • Felbamate • Gavestinel • GV-196,771 • Kynurenic acid • L-689,560 • L-701,324 • Lacosamide • Licostinel • LU-73,068 • MDL-105,519 • Meprobamate • MRZ 2/576 • PNQX • ZD-9379; NR2B subunit antagonists: Besonprodil • CO-101,244 (PD-174,494) • CP-101,606 • Eliprodil • Haloperidol • Ifenprodil • Isoxsuprine • Nylidrin • Ro8-4304 • Ro25-6981 • Traxoprodil; Polyamine site antagonists: Arcaine • Co 101676 • Diaminopropane • Acamprosate • Diethylenetriamine • Huperzine A • Putrescine • Ro 25-6981; Unclassified/unsorted antagonists: Chloroform • Diethyl ether • Enflurane • Ethanol (Alcohol) • Halothane • Isoflurane • Methoxyflurane • Toluene • Trichloroethane • Trichloroethanol • Trichloroethylene • Xylene

Kainate	Agonists: 5-Iodowillardiine • ATPA • Domoic acid • Kainic acid • LY-339,434 • SYM-2081 Antagonists: CNQX • DNQX • LY-382,884 • NBQX • NS102 • Tezampanel • Topiramate • UBP-302; Negative allosteric modulators: NS-3763

Metabotropic

Group I	Agonists: Unselective: ACPD • DHPG • Quisqualic acid; mGlu1-selective: Ro01-6128 • Ro67-4853 • Ro67-7476 • VU-71; mGlu5-selective: ADX-47273 • CDPPB • CHPG • DFB • VU-1545 Antagonists: Unselective: MCPG • NPS-2390; mGlu1-selective: BAY 36-7620 • CPCCOEt • LY-367,385 • LY-456,236; mGlu5-selective: Dipraglurant • DMeOB • Fenobam • LY-344,545 • MPEP • MTEP • SIB-1757 • SIB-1893

Group II	Agonists: Unselective: CBiPES • DCG-IV • Eglumegad • LY-379,268 • LY-404,039 • LY-487,379 • MGS-0028; mGlu2-selective: BINA • LY-566,332 Antagonists: Unselective: APICA • EGLU • HYDIA • LY-307,452 • LY-341,495 • MCPG • MGS-0039: mGlu2-selective: PCCG-4; mGlu3-selective: CECXG

Group III	Agonists: Unselective: L-AP4; mGlu4-selective: PHCCC • VU-001,171 • VU-0155,041; mGlu7-selective: AMN082; mGlu8-selective: DCPG Antagonists: Unselective: CPPG • MAP4 • MSOP • MPPG • MTPG • UBP-1112; mGlu7-selective: MMPIP

Transporter
inhibitors

EAATs	DHKA • PDC • WAY-213,613

vGluTs	7-CKA • Evans blue

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