Negative allosteric modulator

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A negative allosteric modulator (NAM) is a drug which decreases the activity of a receptor indirectly via disactivation of an allosteric site on the protein. NAMs are similar to inverse agonists in that they conteract overall receptor activation, but they are different because they do so in a functionally distinctive way.

Main article: Allosteric regulation

References

Neuromodulation

Types

♦ Enzyme: Inducer
Inhibitor

♦ Ion channel: Opener
Blocker

♦ Receptor: Agonist
Antagonist
Positive allosteric modulator (PAM)
Negative allosteric modulator (NAM)
Inverse agonist

♦ Miscellaneous: Precursor
Cofactor

Classes

Enzyme

see Enzyme inhibition

Ion channel

Receptor &
transporter

BA/M

Adrenergic	Adrenergic receptor agonist (α β (1 2)) Adrenergic receptor antagonist (α (1 2), β) Adrenergic reuptake inhibitor (ARI)

Dopaminergic	Dopamine receptor agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI)

Histaminergic	Histamine receptor agonist Histamine receptor antagonist (H₁ H₂ H₃)

Serotonergic	Serotonin receptor agonist Serotonin Receptor Antagonist (5-HT₃) Serotonin reuptake inhibitor (SRI) Serotonin reuptake enhancer (SRE)


GABAergic	GABA receptor agonist GABA receptor antagonist GABA reuptake inhibitor (GRI)

Glutamatergic	Glutamate receptor agonist (AMPA) Glutamate receptor antagonist (NMDA)

Cholinergic

Endocannabinoid

Opioid

Other

Miscellaneous

Cofactor (see Enzyme cofactors)
Precursor (see Amino acids)

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